Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease.
Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease.
复制标题
DOI：
10.1155/2014/321209
复制
发表时间：
2014
影响因子：
3.1
通讯作者：
Bouvier DS
中科院分区：
文献类型：
--
作者：
Jones EV;Bouvier DS
基质细胞蛋白是分泌的非结构蛋白，其通过调节生长因子信号传导、细胞粘附、迁移和增殖来调节细胞外基质（ECM）和细胞之间的相互作用。尽管在非神经元组织的背景下得到了很好的描述，但最近的研究表明，这些分子也可能在中枢神经系统（CNS）发育和疾病中发挥重要作用。在这篇简短的综述中，我们讨论了基质细胞蛋白家族ESTA（分泌的酸性蛋白和富含半胱氨酸），Hevin/SC 1（SPARC样1），TN-C（腱生蛋白C），TSP（血小板反应蛋白）和CCN（CYR 61/CTGF/NOV），这些蛋白在发育过程中由星形胶质细胞分泌。这些蛋白质在成人CNS中表现出降低的表达，但在损伤或疾病后的反应性星形胶质细胞中上调，其中它们很好地调节修复过程，如组织重塑、轴突再生、神经胶质瘢痕形成、血管生成和神经回路的重新布线。相反，它们在反应性星形胶质细胞中的重新表达也可能导致有害影响并促进神经退行性疾病的进展。
Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.
登录
查看更多内容
影响因子：
34.7
作者：
Clarke, Laura E.;Barres, Ben A.
通讯作者：
Barres, Ben A.
影响因子：
15.9
作者：
Bornstein, P
通讯作者：
Bornstein, P
影响因子：
5.3
作者：
Andrews, Melissa R.;Czvitkovich, Stefan;Fawcett, James W.
通讯作者：
Fawcett, James W.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
11.4
作者：
Blake, Sophia M.;Strasser, Vera;Nimpf, Johannes
通讯作者：
Nimpf, Johannes