Signals and cells involved in regulating liver regeneration.
Signals and cells involved in regulating liver regeneration.
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DOI：
10.3390/cells1041261
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发表时间：
2012-12-13
期刊：
影响因子：
6
通讯作者：
Michalopoulos GK
中科院分区：
文献类型：
--
作者：
Kang LI;Mars WM;Michalopoulos GK
肝脏再生是一种复杂的现象，旨在在损伤导致肝实质丧失的情况下维持恒定的肝脏质量。部分肝切除术后发生一系列事件，涉及促有丝分裂生长因子（HGF，EGF）及其受体（MET和EGFR）控制的多个信号通路。此外，多种细胞因子和其他信号分子有助于协调驱动肝细胞进行DNA合成的信号。肝脏的其他细胞类型接收并向肝细胞传递复杂的信号，以便在再生过程结束时，完整的肝组织被组装，并且再生在适当的时间和适当的肝脏大小终止。如果肝细胞不能参与这一过程，则胆汁隔室被动员以产生祖细胞群，祖细胞群转分化成肝细胞并恢复肝脏大小。
Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controlled by mitogenic growth factors (HGF, EGF) and their receptors (MET and EGFR). In addition multiple cytokines and other signaling molecules contribute to the orchestration of a signal which drives hepatocytes into DNA synthesis. The other cell types of the liver receive and transmit to hepatocytes complex signals so that, in the end of the regenerative process, complete hepatic tissue is assembled and regeneration is terminated at the proper time and at the right liver size. If hepatocytes fail to participate in this process, the biliary compartment is mobilized to generate populations of progenitor cells which transdifferentiate into hepatocytes and restore liver size.