Regional brain and ventricular volumes in Tourette syndrome
Regional brain and ventricular volumes in Tourette syndrome
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DOI：
10.1001/archpsyc.58.5.427
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发表时间：
2001-05-01
影响因子：
--
通讯作者：
Webster, R
中科院分区：
文献类型：
--
作者：
Peterson, BS;Staib, L;Webster, R
背景：多发性抽动症(TS)的病理生理学被认为涉及皮质纹状体-丘脑-皮质回路的紊乱。本研究对155例TS患者和131例健康儿童和成人进行了高分辨率解剖磁共振成像，观察了TS患者大脑皮质和脑白质的形态特征。结果：在包括儿童和成人的分析中，TS受试者的额背区体积较大，顶枕区体积较大，枕下区体积较小。在TS受试者中，脑体积与年龄呈显著负相关，而在健康对照组中则未见。在TS组，健康受试者顶枕区的性别差异减小。与年龄相关的发现在TS儿童中最为突出，而性别差异的缩小在TS成人中最为显著。两组间局部脑室容量的差异不如大脑显著。结论：广泛分布的皮质系统参与了TS的病理生理过程。这些皮质区域的发育过程、性二态和代偿反应可能有助于调节抽动症状的进程和严重程度。
Background: The pathophysiology of Tourette syndrome (TS) is thought to involve disturbances in corticostriato-thalamo-cortical circuitry. The morphological characteristics of the cortical and associated white matter portions of these circuits have not been previously examined in TS subjects.Methods: High-resolution anatomical magnetic resonance images were acquired in 155 TS and 131 healthy children and adults. The cerebrums and ventricles were isolated and then parcellated into subregions using standard anatomical landmarks.Results: For analyses that included both children and adults, TS subjects were found to have larger volumes in dorsal prefrontal regions, larger volumes in parietooccipital regions, and smaller inferior occipital volumes. Significant inverse associations of cerebral volumes with age were seen in TS subjects that were not seen in healthy controls. Sex differences in the parieto-occipital regions of healthy subjects were diminished in the TS group. The age-related findings were most prominent in TS children, whereas the diminished sex differences were most prominent in TS adults. Group differences in regional ventricular volumes were less prominent than in the cerebrum. Regional cerebral volumes were significantly associated with the severity of tic symptoms in orbitofrontal, midtemporal, and parieto-occipital regions.Conclusions: Broadly distributed cortical systems are involved in the pathophysiology of TS. Developmental processes, sexual dimorphisms, and compensatory responses in these cortical regions may help to modulate the course and severity of tic symptoms.