Cerebral abnormalities in cocaine abusers: demonstration by SPECT perfusion brain scintigraphy. Work in progress.
Cerebral abnormalities in cocaine abusers: demonstration by SPECT perfusion brain scintigraphy. Work in progress.
复制标题
可卡因滥用者的大脑异常：SPECT 灌注脑闪烁扫描证实。
作者：
S. Tumeh;J. S. Nagel;R. English;M. Moore;B. Holman
对 12 名承认偶尔或每天使用可卡因的受试者进行了单光子发射计算机断层扫描 (SPECT) 脑部灌注扫描，使用碘 123 异丙基碘苯丙胺 (IMP)。可卡因的给药途径从鼻腔到静脉注射各不相同。还报告了同时滥用其他药物的情况。没有患者的人类免疫缺陷病毒呈阳性。脑部扫描显示 11 名受试者存在局灶性缺陷，其中 7 名受试者无症状，1 名受试者无异常。其中的发现包括分散的局灶性皮质缺损，这种缺损在几名患者中可见，其严重程度从小而少到多发且大不等，特别好发于额叶和颞叶。五名健康志愿者的 I-123 SPECT 图像上未发现灌注缺陷。脑灌注的局灶性改变在无症状吸毒者中常见，并且这些局灶性缺陷很容易通过 I-123 IMP SPECT 描述。
Single photon emission computed tomography (SPECT) perfusion brain scans with iodine-123 isopropyl iodoamphetamine (IMP) were obtained in 12 subjects who acknowledged using cocaine on a sporadic to a daily basis. The route of cocaine administration varied from nasal to intravenous. Concurrent abuse of other drugs was also reported. None of the patients were positive for human immunodeficiency virus. Brain scans demonstrated focal defects in 11 subjects, including seven who were asymptomatic, and no abnormality in one. Among the findings were scattered focal cortical deficits, which were seen in several patients and which ranged in severity from small and few to multiple and large, with a special predilection for the frontal and temporal lobes. No perfusion deficits were seen on I-123 SPECT images in five healthy volunteers. Focal alterations in cerebral perfusion are seen commonly in asymptomatic drug users, and these focal deficits are readily depicted by I-123 IMP SPECT.