Micro- and nanoscopic biotribological behaviours in natural synovial joints and artificial joints
Micro- and nanoscopic biotribological behaviours in natural synovial joints and artificial joints
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DOI：
10.1243/13506501jet245
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发表时间：
2007-03
期刊：
影响因子：
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通讯作者：
T. Murakami;Y. Sawae;K. Nakashima;S. Yarimitsu;T. Sato
中科院分区：
文献类型：
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作者：
T. Murakami;Y. Sawae;K. Nakashima;S. Yarimitsu;T. Sato
摘要 为了保持自然滑膜关节和人工软骨关节假体的低摩擦和低磨损，微米和纳米水平的吸附膜形成似乎在发生局部直接接触的混合或边界润滑状态中发挥着重要作用。在自然滑膜关节中，即使在去除吸附膜后，润滑凝胶膜也可能保持低摩擦并保护大块软骨。对于聚乙烯醇（PVA）水凝胶作为没有润滑凝胶层的人工软骨，吸附膜是单一的保护屏障。在之前对PVA本身或玻璃板摩擦对的研究中，白蛋白（A）和γ-球蛋白（G）以A：G = 1：2共存，在透明质酸溶液中总蛋白浓度为2.1 wt％时表现出最低的磨损。本研究对蛋白质的吸附进行了原位观察，以阐明含有不同蛋白质成分的润滑剂吸附行为的动态变化。在混合润滑状态下，白蛋白和γ-球蛋白以A:G = 1:2共存时摩擦力最低。基于先前和当前的结果，讨论了蛋白质适当成分在微观和纳米水平上的低摩擦和低磨损的作用。
Abstract To maintain low friction and low wear in natural synovial joints and joint prostheses with artificial cartilage, adsorbed film formation at micro- and nanoscopic levels appears to play an important role in mixed or boundary lubrication regime where local direct contact occurs. In natural synovial joints, the lubricating gel film is likely to preserve low friction and to protect the bulk cartilage even after the removal of the adsorbed film. For poly (vinyl alcohol) (PVA) hydrogel as artificial cartilage without lubricating gel layer, the adsorbed film is a single protective barrier. In the previous researches on the rubbing pair of PVA against itself or glass plate, the coexistence of albumin (A) and γ-globulin (G) as A:G = 1: 2 at total protein concentration of 2.1 wt% in hyaluronate solution showed the lowest wear. In this study, in situ observation of adsorption of proteins was conducted to clarify the dynamic changes in adsorptional behaviours in lubricants containing different protein constituents. In the mixed lubrication regime, the coexistence of albumin and γ-globulin as A:G = 1:2 showed the lowest friction. The role of appropriate constituents of proteins is discussed on low friction and low wear at micro- and nanoscopic levels on the basis of previous and present results.