Effect of polyester-based artificial tendons on movement biomechanics: A preliminary in vivo study
Effect of polyester-based artificial tendons on movement biomechanics: A preliminary in vivo study
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DOI：
10.1016/j.jbiomech.2023.111520
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发表时间：
2023-03-20
影响因子：
2.4
通讯作者：
Crouch，Dustin L.
中科院分区：
文献类型：
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作者：
Hall，Patrick T.;Stubbs，Caleb;Crouch，Dustin L.
人工肌腱可能是替代受损或缺失的生物肌腱的有价值的临床装置。在这项初步研究中，我们量化了基于聚酯缝合线的人工肌腱对运动生物力学的影响。新西兰白兔接受了用人工肌腱替换跟腱 (n = 2) 或胫骨颅肌 (TC, n = 2) 生物肌腱的手术。我们在术前和术后 2 至 6 周内每周量化一次跳跃步态站立阶段的后肢运动学和地面接触压力。随着时间的推移，两组的术后运动生物力学要么保持一致，要么有所改善。然而，跟腱组的整体生物力学和肌肉缺陷比 TC 组更大。在 TC 组中，术后 6 周时，在前 30% 的站立姿势中，足部角度比健康对照组大约 10°。术后 6 周，跟健康对照组相比（分别为 65.0 ± 11.2° 和 50.2 ± 8.3% BW），跟腱组在站立时表现出更小的（即更多背屈）踝关节角度（最小角度 = 31.5 ± 9.4°）和垂直地面反作用力（37.4 ± 2.6% BW）。未来的研究需要量化人工肌腱的长期生物力学功能、人工肌腱对肌肉功能和结构的影响以及正式康复的效果。
Artificial tendons may be valuable clinical devices for replacing damaged or missing biological tendons. In this preliminary study, we quantified the effect of polyester-suture-based artificial tendons on movement biomechanics. New Zealand White rabbits underwent surgical replacement of either the Achilles (n = 2) or tibialis cranialis (TC, n = 2) biological tendons with artificial tendons. Once pre-surgery and weekly from 2 to 6 weeks post-surgery, we quantified hindlimb kinematics and ground contact pressures during the stance phase of hopping gait. Post-surgical movement biomechanics were either consistent or improved over time in both groups. However, the Achilles group had greater overall biomechanical and muscle deficits than the TC group. In the TC group, at 6 weeks post-surgery, foot angles were about 10° greater than those in healthy controls during the first 30 % of stance. At 6 weeks post-surgery, the Achilles group exhibited lesser (i.e., more dorsiflexed) ankle angles (minimum angle = 31.5 ± 9.4°) and vertical ground reaction forces (37.4 ± 2.6 %BW) during stance than those in healthy controls (65.0 ± 11.2° and 50.2 ± 8.3 %BW, respectively). Future studies are needed to quantify long-term biomechanical function with artificial tendons, the effect of artificial tendons on muscle function and structure, and the effect of formal rehabilitation.