Effects of maternal magnesium sulfate treatment on newborns
Effects of maternal magnesium sulfate treatment on newborns
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母体硫酸镁治疗对新生儿的影响
DOI：
10.1111/ped.14747
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发表时间：
2021
影响因子：
1.4
通讯作者：
Okumura Akihisa
中科院分区：
文献类型：
--
作者：
Numoto Shingo;Kakita Hiroki;Takeshita Satoru;Ueda Hiroko;Kondo Tomoko;Kurahashi Hirokazu;Wakatsuki Akihiko;Yamada Yasumasa;Okumura Akihisa
孕期硫酸镁(MgSO4)已用于母亲，但对胎儿的影响尚不清楚。本研究的目的是确定产前长期接触硫酸镁是否与新生儿的不良反应相关。方法收集77例母亲服用硫酸镁所生婴儿的临床资料。结果婴儿血清镁水平与母亲镁浓度呈正相关，与镁治疗时间及镁累积剂量无关。无论是镁治疗的时间长短还是镁的累积剂量，婴儿的临床变量都没有显著差异。相反，血清镁水平为≥4.0 //L的婴儿开始肠内喂养耐受的年龄明显较晚，入院时的心率明显低于血清镁水平为4.0 /L的婴儿。结论血清镁水平较高的婴儿对临床变量的影响最大，但镁治疗时间和累积镁剂量与婴儿的临床变量无关。因此，在血清镁水平仅中度升高的新生儿中，不太可能出现严重的不良反应。
BackgroundAntenatal magnesium sulfate (MgSO4) has been used with mothers, but the influence of MgSO4on the fetus is unclear. The purpose of this study is to determine whether longer antenatal MgSO4exposure correlates with adverse effects in newborns.MethodsThe clinical data of 77 infants born to mothers treated with MgSO4were collected. The infants were divided into two groups according to (1) the serum Mg concentration, (2) cumulative Mg dose, and (3) duration of antenatal maternal Mg treatment, respectively.ResultsThe serum Mg level of the infants correlated with that of the mothers but not with the duration of Mg treatment or the cumulative dose of Mg. There were no significant differences in the infants’ clinical variables according to either the duration of Mg treatment or the cumulative dose of Mg. By contrast, enteral feeding tolerance began at a significantly later age and the heart rate on admission was significantly lower in infants with a serum Mg level ≥4.0 mmol/L than in those with a serum Mg level <4.0 mmol/L.ConclusionsModest effects on the clinical variables of infants with higher serum Mg levels were determined, whereas neither the duration of Mg treatment nor the cumulative Mg dose correlated with the clinical variables of the infants. Thus, in newborns with only moderately elevated serum Mg levels, serious adverse effects are unlikely.