Hepatitis B virus, the vaccine, and the control of primary cancer of the liver
Hepatitis B virus, the vaccine, and the control of primary cancer of the liver
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DOI：
10.1073/pnas.94.14.7121
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发表时间：
1997-07-08
影响因子：
11.1
通讯作者：
Blumberg, BS
中科院分区：
文献类型：
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作者：
Blumberg, BS
本文介绍了一个基础研究项目，该项目最初旨在了解人类遗传多态性在遗传易感性疾病中的作用。起初，这个项目没有明显的实际应用。然而，建立在过去几十年对肝炎的大量研究的基础上，这些研究导致了B型肝炎病毒（HBV）的发现，病毒检测的诊断方法和疫苗。这些应用对世界范围内的医疗和公共卫生问题产生了重大影响。这些发现和应用挽救了许多生命，也具有重大的经济价值。参考文献中给出了其他信息和参考文献。1-4.
This paper describes a project in basic research, which initially was designed to understand the role of human genetic polymorphisms in relation to inherited susceptibility to disease. At the onset, there was no obvious practical application of this project. However, building on a large body of research on hepatitis over the preceding decades, these studies resulted in the discovery of the hepatitis B virus (HBV), diagnostic methods for viral detection, and a vaccine. These applications have had a major impact on worldwide medical and public health problems. The discoveries and applications have saved many lives and also have been of significant economic value. Additional information and references are given in refs. 1–4.