Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
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DOI：
10.1016/s1074-7613(02)00483-1
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发表时间：
2002-12-01
期刊：
影响因子：
32.4
通讯作者：
Tedder, TF
中科院分区：
文献类型：
--
作者：
Haas, KM;Hasegawa, M;Tedder, TF
CD21/35受体在固有免疫和适应性免疫之间提供了重要联系。利用一种全新的CD21/35表达完全缺失的小鼠品系（CD21/35（-/-））评估了其在针对有荚膜的胞外细菌的保护性免疫应答中的重要性。CD21/35表达对于体内B细胞快速捕获C3dg - 抗原复合物至关重要，特别是在脾脏边缘区。尽管CD21/35（-/-）小鼠的B细胞发育正常，但对低剂量抗原的T细胞非依赖性和依赖性抗体应答显著降低，IgG3应答明显受损。相应地，CD21/35（-/-）小鼠对急性致死性肺炎链球菌感染更易感。因此，CD21/35表达对于针对快速繁殖并迅速使免疫系统不堪重负的致死性病原体的早期保护性抗体应答至关重要。
The CD21/35 receptor provides an important link between innate and adaptive immunity. Its importance during protective immune responses to encapsulated extracellular bacteria was assessed using a new line of mice completely deficient in CD21/35 expression (CD21/35(-/-)). CD21/35 expression was essential for the rapid trapping of C3dg-antigen complexes by B cells in vivo, especially in splenic marginal zones. Despite normal B cell development in CD21/35(-/-) mice, T cell-independent and -dependent antibody responses to low-dose antigens were significantly decreased, with a striking impairment in IgG3 responses. Accordingly, CD21/35(-/-) mice were more susceptible to acute lethal Streptococcus pneumoniae infection. Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system.