Evidence for hysteresis in the cerebral pressure-flow relationship in healthy men
Evidence for hysteresis in the cerebral pressure-flow relationship in healthy men
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DOI：
10.1152/ajpheart.00790.2016
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发表时间：
2017-04-01
影响因子：
4.8
通讯作者：
Ainslie, Philip N.
中科院分区：
文献类型：
--
作者：
Brassard, Patrice;Ferland-Dutil, Helene;Ainslie, Philip N.
与短暂性低血压相比，动脉血管系统更有效地补偿动脉导管引起的短暂性高血压。这种现象是否存在于非药物性高血压和低血压中目前尚不清楚。我们比较了58名男性志愿者在0.05 Hz（20 s周期）和0.10 Hz（10 s周期）下进行蹲立动作诱导的短暂高血压和低血压期间大脑中动脉平均流速（MCAv平均）的百分比变化与平均动脉压（MAP）的百分比变化（% Δ MCAv平均/% Δ MAP）。短暂性高血压与低血压相比，%Delta MCA v平均值/%Delta MAP分别降低25%（P = 0.03，0.05 Hz）和47%（P < 0.0001，0.10 Hz）。因此，这些研究结果表明，在健康男性的大脑是更好地适应，以弥补生理相关的短暂高血压比hypothes.NEW & NOTEWORTHY新的发现，这项研究是大脑中动脉平均流速的变化衰减高血压期间相比，生理引起的低血压在男性的血压振荡。这些结果支持人脑在补偿短暂性高血压方面比低血压更有效。
The cerebrovasculature is more efficient at compensating for pharmacologically induced transient hypertension versus transient hypotension. Whether this phenomenon exists during nonpharmacologically induced hypertension and hypotension is currently unknown. We compared the percent change in mean velocity in the middle cerebral artery (MCAvmean) per percent change in mean arterial pressure (MAP) (%Delta MCAVmean/%Delta MAP) during transient hypertension and hypotension induced during squatstand maneuvers performed at 0.05 Hz (20-s cycles) and 0.10 Hz (10-s cycles) in 58 male volunteers. %Delta MCAvmean/%Delta MAP was attenuated by 25% (P = 0.03, 0.05 Hz) and 47% (P < 0.0001, 0.10 Hz) during transient hypertension versus hypotension. Thus, these findings indicate that the brain in healthy men is better adapted to compensate for physiologically relevant transient hypertension than hypotension.NEW & NOTEWORTHY The novel finding of this study is that the change in middle cerebral artery mean flow velocity is attenuated during hypertension compared with hypotension physiologically induced by oscillations in blood pressure in men. These results support that the human brain is more effective at compensating for transient hypertension than hypotension.