Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease.
Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease.
复制标题
中药清热解毒治疗非酒精性脂肪肝的多靶点治疗机制
DOI：
10.18632/oncotarget.15482
复制
发表时间：
2017-04-25
期刊：
影响因子：
--
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Feng Q;Liu W;Baker SS;Li H;Chen C;Liu Q;Tang S;Guan L;Tsompana M;Kozielski R;Baker RD;Peng J;Liu P;Zhu R;Hu Y;Zhu L
研究人员观察了中草药祛湿化瘀汤（QHD）对非酒精性脂肪肝（NAFLD）患者和动物模型的有益作用。使用 NAFLD 大鼠检查 QHD 或其活性成分（京尼平苷和绿原酸，GC）对 NAFLD 肝脏转录组和肠道微生物群的影响。在用 QHD 和 GC 治疗的 NAFLD 肝脏中观察到谷胱甘肽生成所需基因的表达增加和脂质合成所需基因的表达减少。 GC 治疗降低了血清 LPS，这可以通过 GC 治疗的大鼠结肠粘膜损伤减少来解释。此外，我们的数据表明，Treg 诱导细菌的丰度增加，刺激了 GC 处理的结肠中的 Treg 活性，进而下调炎症信号，改善肠道屏障功能，从而减少肝脏对微生物产物的暴露。我们的研究表明，QHD 同时增强肝脏抗氧化机制，减少肝脏脂质合成，并促进调节性 T 细胞诱导肠道微生物群。
Beneficial effects of the Chinese herbal medicine Qushi Huayu Decoction (QHD) were observed with non-alcoholic fatty liver disease (NAFLD) patients and animal models. The impact of QHD or its active components (geniposide and chlorogenic acid, GC) on NAFLD liver transcriptome and gut microbiota was examined with NAFLD rats. Increased expression for genes required for glutathione production and decreased expression for genes required for lipid synthesis was observed in NAFLD livers treated with QHD and GC. GC treatment decreased serum LPS, which could be explained by reduced mucosal damage in the colon of GC-treated rats. Further, our data suggest an increased abundance of Treg-inducing bacteria that stimulated the Treg activity in GC treated colon, which in turn down-regulated inflammatory signals, improved gut barrier function and consequently reduced hepatic exposure to microbial products. Our study suggests that QHD simultaneously enhanced the hepatic anti-oxidative mechanism, decreased hepatic lipid synthesis, and promoted the regulatory T cell inducing microbiota in the gut.