Incidence of radiologically-confirmed pneumonia and Haemophilus influenzae type b carriage before Haemophilus influenzae type b conjugate vaccine introduction in Central Vietnam.
Incidence of radiologically-confirmed pneumonia and Haemophilus influenzae type b carriage before Haemophilus influenzae type b conjugate vaccine introduction in Central Vietnam.
复制标题
越南中部引入 B 型流感嗜血杆菌结合疫苗之前，放射学确诊的肺炎和 B 型流感嗜血杆菌携带的发病率。
DOI：
10.1016/j.jpeds.2013.03.029
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发表时间：
2013
影响因子：
5.1
通讯作者：
Ariyoshi K.
中科院分区：
文献类型：
--
作者：
Yoshida LM;Nguyen HA;Watanabe K;Le MN;Nguyen AT;Vu HT;Yoshino H;Suzuki M;Takahashi K;Le T;Moriuch H;Kilgore PE;Edmond K;Mulholland K;Dang DA;Ariyoshi K.
在HiB结合疫苗引入之前，确定越南中部放射学证实的肺炎（RCP）和流感嗜血杆菌B型（HiB）携带的发病率作为基线数据。研究在正在进行的基于人群的前瞻性住院急性呼吸道感染监测研究的背景下，在1000名居住在芽庄的< 5岁儿童中进行了横断面HiB携带研究，2010年6月，在越南全国范围内引入Hib结合疫苗前1个月，在越南，< 5岁儿童中RCP住院的发生率为每1000名儿童3.3例。12-23个月年龄组儿童的发病率最高（每1 000人中有8.3人）。流感嗜血杆菌携带率为37%，Hib携带率为3%。82%的流感嗜血杆菌携带TEM β-内酰胺酶耐药基因。6个或更多家庭成员的存在与Hib携带率的增加有关（P = 0.04）。需要继续监测侵入性Hib疾病和连续的Hib携带调查，以支持未来评估Hib结合疫苗在越南的影响。
OBJECTIVESTo determine the incidence of radiologically-confirmed pneumonia (RCP) and Haemophilus influenzae type b (Hib) carriage in central Vietnam as a baseline data before Hib conjugate vaccine introduction.STUDY DESIGNIn the context of ongoing population-based prospective, hospitalized acute respiratory infection surveillance study, a cross-sectional Hib carriage study was conducted among 1000 children < 5 years of age living in NhaTrang, Vietnam in June 2010, 1 month before the nationwide introduction of Hib conjugate vaccine in Vietnam.RESULTSThe incidence of RCP hospitalizations among children < 5 years of age was 3.3 per 1000 children. The highest incidence was observed among children 12-23 month age group (8.3 per 1000). Haemophilus influenzae carriage was detected in 37% of the children and Hib carriage rate was 3%. Eighty-two percent of the Haemophilus influenzae had TEM β-lactamase resistance gene. The presence of 6 or more family members was associated with an increased rate of Hib carriage (P = .04).CONCLUSIONSIncidence of RCP and Hib carriage in this cross-sectional survey are lower compared with other studies. Continued surveillance for invasive Hib disease and sequential Hib carriage surveys are needed to support future assessments of the impact of Hib conjugate vaccine in Vietnam.