Adverse effects of dibutyltin dichloride on initiation and maintenance of rat pregnancy
Adverse effects of dibutyltin dichloride on initiation and maintenance of rat pregnancy
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DOI：
10.1016/s0890-6238(00)00095-2
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Harazono, A
中科院分区：
文献类型：
--
作者：
Ema, M;Harazono, A
本研究旨在评估大鼠妊娠早期母体接触二丁基二氯化锡（DBTCl）后对妊娠启动和维持的不良影响。成功交配后，雌性大鼠在妊娠第0 - 3天或第4 - 7天通过胃插管给予0、3.8、7.6或15.2 mg/kg的DBTCl。在妊娠第0 - 3天或第4 - 7天，给予食物限制妊娠大鼠的饲料量等于用15.2 mg/kg DBTCl处理的雌性大鼠的饲料摄入量。在妊娠第20天处死雌性大鼠，并测定妊娠结局。在第0 - 3天给予DBTCl后，7.6 mg/kg组的未妊娠雌性动物率和着床前胚胎丢失发生率显著高于对照组，15.2 mg/kg组显著高于对照组和配对喂养组。在发生流产的雌性动物中，第0 - 3天给予DBTCl的各组中流产和活胎数量以及着床后胚胎丢失的发生率与对照组无显著差异。在第4 - 7天以7.6和15.2 mg/kg剂量给予DBTCl的组中，植入后胚胎丢失的发生率显著高于对照组和配对喂养组。可以得出结论，当在妊娠早期施用时，DBTCl对妊娠的开始和维持产生不利影响，并且DBTCl的不利影响的表现随母体暴露时的妊娠阶段而变化。(C)2000 Elsevier Science Inc. All rights reserved.
The present study was conducted to evaluate the adverse effects of dibutyltin dichloride (DBTCl) on initiation and maintenance of pregnancy after maternal exposure during early pregnancy in rats. After successful mating, female rats were given DBTCl by gastric intubation on Days 0 to 3 or on Days 4 to 7 of pregnancy at 0, 3.8, 7.6, or 15.2 mg/kg. Food-restricted pregnant rats were given an amount of feed equal to the feed intake of female rats treated with DBTCl at 15.2 mg/kg on Days 0 to 3 or on Days 4 to 7 of pregnancy. Female rats were sacrificed on Day 20 of pregnancy and pregnancy outcome was determined. After administration of DBTCl on Days 0 to 3, the rate of nonpregnant females and the incidence of preimplantation embryonic loss in the 7.6 mg/kg group were significantly higher than those in the control group, and those in the 15.2 mg/kg group were significantly higher than those in the control and pair-fed groups. In females with implantations, the numbers of implantations and live fetuses and the incidence of postimplantation embryonic loss in the groups given DBTCl on Days 0 to 3 were not significantly different from those in the control group. The incidence of postimplantation embryonic loss in the groups given DBTCl on Days 4 to 7 at 7.6 and 15.2 mg/kg was significantly higher than that in the control and pair-fed groups. It can be concluded that DBTCl adversely affects initiation and maintenance of pregnancy when administered during early pregnancy and that the manifestations of the adverse effects of DBTCl vary with the gestational stage at the time of maternal exposure. (C) 2000 Elsevier Science Inc. All rights reserved.