Miniaturized Systems for Homogeneously and Heterogeneously Catalyzed Liquid-Phase Esterification Reaction
Miniaturized Systems for Homogeneously and Heterogeneously Catalyzed Liquid-Phase Esterification Reaction
复制标题
DOI：
10.1021/ie060411
复制
发表时间：
2007-06
影响因子：
4.2
通讯作者：
A. Kulkarni;K. Zeyer;T. Jacobs;A. Kienle
中科院分区：
文献类型：
--
作者：
A. Kulkarni;K. Zeyer;T. Jacobs;A. Kienle
本文提出了一种用于分析均相和非均相酸催化乙酸丁醇酯化反应的模拟装置概念。该设备配置包括微混合器，随后是等温微反应器。对于均相催化酯化的情况，内径为1.3 mm的长管用作反应管，并且还有助于实现更长的停留时间。发现结果与用实验室规模的常规设备获得的文献数据一致，而在长反应时间和高催化剂浓度下观察到偏差。以Amberlyst-15为催化剂，设计了一种新型的小型固定床反应器（mFBR）。mFBR的性能在很长一段时间内是令人满意的，是可重复的，并且可以用于连续合成。通过改变反应器的总流量和反应板数，可以改变停留时间和反应长度。
A miniaturized-plant concept is presented for the analysis of homogeneous and heterogeneous acid-catalyzed esterification of acetic acid with butanol. The plant configuration includes a micromixer followed by an isothermal microreactor. For the case of homogeneously catalyzed esterification, a long tube of 1.3 mm inner diameter acted as the reaction tube and also helped to achieve longer residence times. The results were found to be consistent with the data from literature obtained with conventional equipment on lab scale, while deviations were seen at long reaction times and high catalyst concentrations. A novel miniaturized fixed-bed reactor (mFBR) was designed for the heterogeneously catalyzed reaction, with Amberlyst-15 as a catalyst. The performance of the mFBR was satisfactory for a very long time, was reproducible, and could be used for continuous synthesis. A change in the residence time and the reactive length can be achieved by changing the total flow rate and the number of reaction plates in th...