Unsafe "crossover-use" of chloramphenicol in Uganda: importance of a One Health approach in antimicrobial resistance policy and regulatory action.
Unsafe "crossover-use" of chloramphenicol in Uganda: importance of a One Health approach in antimicrobial resistance policy and regulatory action.
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DOI：
10.1038/s41429-021-00416-3
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Clarke SE
中科院分区：
文献类型：
--
作者：
McCubbin KD;Ramatowski JW;Buregyeya E;Hutchinson E;Kaur H;Mbonye AK;Mateus ALP;Clarke SE
自从抗生素被引入主流医疗保健以来，对这些药物的耐药性已成为一个普遍的问题，在世界范围内持续增加。由于目前缺乏低收入国家抗生素产品供应和使用的监测数据，减缓抗生素耐药性发展的政策决定受到阻碍。本研究收集了乌干达卢韦罗区5个县的人用（42家）和兽用（21家）药店库存抗生素的数据。与药店供应商的焦点小组讨论也被用来探索社区中的抗生素使用实践。焦点小组的参与者报告说，农民使用人用抗生素喂养牲畜，社区成员获得动物用抗生素供自己个人使用。具体而言，乌干达的家禽正在使用许可供人使用的氯霉素产品。人类通过当地动物产品食用氯霉素残留是一个严重的公共卫生问题。通过将卫生部门的抗菌素耐药性研究范围限制在人类或动物抗生素的使用，结果可能会错误地告知政策和干预战略。因此，需要一个健康的方法来了解社区抗生素使用的更广泛的影响，并提高干预政策和监管行动的整体有效性。
Since the introduction of antibiotics into mainstream health care, resistance to these drugs has become a widespread issue that continues to increase worldwide. Policy decisions to mitigate the development of antimicrobial resistance are hampered by the current lack of surveillance data on antibiotic product availability and use in low-income countries. This study collected data on the antibiotics stocked in human (42) and veterinary (21) drug shops in five sub-counties in Luwero district of Uganda. Focus group discussions with drug shop vendors were also employed to explore antibiotic use practices in the community. Focus group participants reported that farmers used human-intended antibiotics for their livestock, and community members obtain animal-intended antibiotics for their own personal human use. Specifically, chloramphenicol products licensed for human use were being administered to Ugandan poultry. Human consumption of chloramphenicol residues through local animal products represents a serious public health concern. By limiting the health sector scope of antimicrobial resistance research to either human or animal antibiotic use, results can falsely inform policy and intervention strategies. Therefore, a One Health approach is required to understand the wider impact of community antibiotic use and improve overall effectiveness of intervention policy and regulatory action.
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影响因子：
2.8
作者：
Mayora C;Kitutu FE;Kandala NB;Ekirapa-Kiracho E;Peterson SS;Wamani H
通讯作者：
Wamani H
影响因子：
5.4
作者：
Chandler, Clare I. R.;Hall-Clifford, Rachel;Asaph, Turinde;Pascal, Magnussen;Clarke, Sian;Mbonye, Anthony K.
通讯作者：
Mbonye, Anthony K.
影响因子：
3.1
作者：
Ssajjakambwe, Paul;Bahizi, Gloria;Kaneene, John B
通讯作者：
Kaneene, John B
影响因子：
4.5
作者：
Biswas, Mohitosh;Roy, Manobendro Nath;Sultana, Sharmin
通讯作者：
Sultana, Sharmin
影响因子：
8.1
作者：
Hutchinson E;Hutchison C;Lal S;Hansen K;Kayendeke M;Nabirye C;Magnussen P;Clarke SE;Mbonye A;Chandler CIR
通讯作者：
Chandler CIR