Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior.
Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior.
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DOI：
10.1016/j.envint.2017.01.006
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发表时间：
2017-04
影响因子：
11.8
通讯作者：
Lefebvre KA
中科院分区：
文献类型：
--
作者：
Ferriss BE;Marcinek DJ;Ayres D;Borchert J;Lefebvre KA
软骨藻酸(DA)是一种神经毒素，由浮游植物自然产生，在有害的藻类水华期间在海产品中积累。随着DA在海洋环境中的流行程度增加，迫切需要确定有DA中毒风险的海产品消费者。对休闲剃刀蚌(Siliqua Patula)收割机的DA暴露进行了估计，以确定是否发生高于当前监管准则的暴露和/或收割机是否长期暴露于低水平的DA。2015年春季和2016年冬季，美国华盛顿州对休闲采集机进行了1523次调查，确定了人类对剃刀文蛤的消耗率。这些消耗率数据与一个州监测项目收集的剃须刀蚌中的DA测量相结合，以估计人类DA的暴露。在计算的总急性暴露剂量中(包括同一人在不同时间)，大约有7%超过了当前的监管参考剂量(0.075 mg DA·kg Bodyweight−1·d−1)，原因是消耗率高于以前报告的水平、体重较低和/或以法定DA水平上限(整个组织最大20 mg·kg−1湿重)摄入了文蛤。3%的调查受访者连续12个月每月至少消费15个文蛤，有可能面临长期接触DA的风险。这些对DA消费的洞察将为刀蛤渔业管理提供另一种工具。
Domoic acid (DA) is a neurotoxin that is naturally produced by phytoplankton and accumulates in seafood during harmful algal blooms. As the prevalence of DA increases in the marine environment, there is a critical need to identify seafood consumers at risk of DA poisoning. DA exposure was estimated in recreational razor clam (Siliqua patula) harvesters to determine if exposures above current regulatory guidelines occur and/or if harvesters are chronically exposed to low levels of DA. Human consumption rates of razor clams were determined by distributing 1,523 surveys to recreational razor clam harvesters in spring 2015 and winter 2016, in Washington, USA. These consumption rate data were combined with DA measurements in razor clams, collected by a state monitoring program, to estimate human DA exposure. Approximately seven percent of total acute exposures calculated (including the same individuals at different times) exceeded the current regulatory reference dose (0.075 mg DA· kg bodyweight−1 · d−1) due to higher than previously reported consumption rates, lower body weights, and/or by consumption of clams at the upper range of legal DA levels (maximum 20 mg · kg−1 wet weight for whole tissue). Three percent of survey respondents were potentially at risk of chronic DA exposure by consuming a minimum of 15 clams per month for at 12 consecutive months. These insights into DA consumption will provide an additional tool for razor clam fishery management.