THE ORIGIN, COURSE, AND TERMINATION OF THE HIPPOCAMPOTHALAMIC PROJECTIONS IN THE MACAQUE
THE ORIGIN, COURSE, AND TERMINATION OF THE HIPPOCAMPOTHALAMIC PROJECTIONS IN THE MACAQUE
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DOI：
10.1002/cne.902430310
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发表时间：
1986-01-15
影响因子：
2.5
通讯作者：
MISHKIN, M
中科院分区：
文献类型：
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作者：
AGGLETON, JP;DESIMONE, R;MISHKIN, M
用顺行和逆行示踪剂研究了海马结构向丘脑的投射。辣根过氧化物酶注射到内侧和中线丘脑网站在6例，和氚化氨基酸注射到海马结构在9人，其中5人有前穹窿横断。只有下丘脑和内嗅皮质被发现投射到丘脑。从下托皮质，密集的双边预测跟踪通过穹窿的前核，而较轻的穹窿预测终止于其他吻中线网站，包括核reuniens，centralis latocellularis，和室旁。这些突起主要来自位于下托和前下托最深细胞层的多形细胞。此外，发现下托皮质投射到外侧背核。后一种投射显示出粗糙的地形组织，它穿过穹窿，或者与其他下托传出神经不同，穿过内囊的豆状核下支，形成阿诺德颞枕束的一部分。非穹窿向背外侧核的投射穿过内侧枕，在那里有一些额外的终止。从内嗅皮层到丘脑的投射很少（如果有的话）经过穹窿。相反，内嗅传出进行下丘脑脚的大细胞部分的背内侧核，并在内囊和Arnold束的内侧枕和背外侧核。
The projections from the hippocampal formation to the thalamus were investigated with both anterograde and retrograde tracers. Horseradish peroxidase was injected into medial and midline thalamic sites in six cases, and tritiated amino acids were injected into the hippocampal formation in nine others, five of which had prior transections of the fornix. Only the subicular and entorhinal cortices were found to project to the thalamus. From the subicular cortex, dense bilateral projections were traced through the fornix to the anterior nuclei, while lighter fornical projections terminated in other rostral midline sites, including the nuclei reuniens, centralis latocellularis, and paraventricularis. These projections arose predominantly from the polymorphic cells which are located in the deepest cellular layers of the subiculum and prosubiculum. In addition, the subicular cortex was found to project to the nucleus lateralis dorsalis. The latter projection, which showed evidence of a crude topographic organization, ran either through the fornix or, unlike the other subicular efferents, through the sublenticular limb of the internal capsule to form part of the temporopulvinar bundle of Arnold. The nonfornical projection to the nucleus lateralis dorsalis passed through the medial pulvinar, where there was some additional termination. Few, if any, projections from the entorhinal cortex to the thalamus travelled in the fornix. Rather, the entorhinal efferents were carried in the inferior thalamic peduncle to the magnocellular portion of the nucleus medialis dorsalis, and in the internal capsule and bundle of Arnold to the medial pulvinar and the nucleus lateralis dorsalis.