Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development.
Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development.
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DOI：
10.1128/msystems.00122-17
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发表时间：
2018-01
期刊：
影响因子：
6.4
通讯作者：
Bohannan BJM
中科院分区：
文献类型：
--
作者：
Stagaman K;Cepon-Robins TJ;Liebert MA;Gildner TE;Urlacher SS;Madimenos FC;Guillemin K;Snodgrass JJ;Sugiyama LS;Bohannan BJM
先前的研究报告了居住在富裕国家与贫穷国家的人群之间肠道微生物组的差异，导致断言与经济发展相关的生活方式变化促进了肠道微生物组的变化，从而促进了微生物组相关疾病的扩散。然而，经济发展与肠道微生物组之间的直接关系此前尚未得到证实。我们调查了一个正在经历经济发展的土著人口的肠道微生物组，发现肠道微生物组的特征与经济发展相关的生活方式变化之间存在显著关联。这些发现表明，即使是经济发展的最早阶段也会推动肠道微生物组的变化，这可能为微生物组相关疾病的发展提供警告信号。经济发展的特点是微生物组相关疾病的发病率急剧增加，如自身免疫性疾病和代谢综合征，但驱动人类微生物组改变的生活方式变化尚不清楚。我们将市场一体化作为经济相关生活方式属性的代表进行衡量，例如特定市场商品的所有权，这些商品衡量了市场一体化程度以及传统和非传统（更现代）房屋结构和基础设施的组成部分，并描述了来自邻近的厄瓜多尔原住民的213名参与者的粪便微生物组。尽管整个人群的生活方式差异相对较小，但更大的经济发展与宿主内多样性显着降低，宿主间差异更高以及细菌普雷沃氏菌相对丰度的下降相关。这些微生物群的变化与更现代化的住房密切相关，其次是传统生计生活方式相关物品的所有权减少。以前的研究报告了居住在富裕国家和贫穷国家的人群之间肠道微生物组的差异，导致断言与经济发展相关的生活方式变化促进了肠道微生物组的变化，从而促进了微生物组相关疾病的扩散。然而，经济发展与肠道微生物组之间的直接关系此前尚未得到证实。我们调查了一个正在经历经济发展的土著人口的肠道微生物组，发现肠道微生物组的特征与经济发展相关的生活方式变化之间存在显著关联。这些发现表明，即使是经济发展的最早阶段也会推动肠道微生物组的变化，这可能为微生物组相关疾病的发展提供警告信号。
Previous research has reported differences in the gut microbiome between populations residing in wealthy versus poorer countries, leading to the assertion that lifestyle changes associated with economic development promote changes in the gut microbiome that promote the proliferation of microbiome-associated diseases. However, a direct relationship between economic development and the gut microbiome has not previously been shown. We surveyed the gut microbiomes of a single indigenous population undergoing economic development and found significant associations between features of the gut microbiome and lifestyle changes associated with economic development. These findings suggest that even the earliest stages of economic development can drive changes in the gut microbiome, which may provide a warning sign for the development of microbiome-associated diseases. Economic development is marked by dramatic increases in the incidence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items. IMPORTANCE Previous research has reported differences in the gut microbiome between populations residing in wealthy versus poorer countries, leading to the assertion that lifestyle changes associated with economic development promote changes in the gut microbiome that promote the proliferation of microbiome-associated diseases. However, a direct relationship between economic development and the gut microbiome has not previously been shown. We surveyed the gut microbiomes of a single indigenous population undergoing economic development and found significant associations between features of the gut microbiome and lifestyle changes associated with economic development. These findings suggest that even the earliest stages of economic development can drive changes in the gut microbiome, which may provide a warning sign for the development of microbiome-associated diseases.