Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis
Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis
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DOI：
10.1002/dvdy.10485
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发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Trainor, PA
中科院分区：
文献类型：
--
作者：
Kulesa, P;Ellies, DL;Trainor, PA
颅神经嵴细胞是一个多能的、可迁移的细胞群，产生脊椎动物头部的大部分软骨、骨、结缔组织和周围神经系统。正常的颅面形态发生需要适当的神经嵴细胞模式，并且在脊椎动物中高度保守。神经嵴细胞模式与神经管的早期分割密切相关，因此神经嵴细胞以离散的分离流迁移。活胚胎成像的最新进展已经开始揭示神经嵴细胞的复杂行为，其中涉及复杂的细胞-细胞和细胞-环境相互作用。尽管不同脊椎动物物种之间神经嵴细胞迁移的总体相似性，但存在重要的机制差异。例如，细胞凋亡对于鸡胚胎中的神经嵴细胞图案化是重要的，但在小鼠、青蛙或鱼胚胎中不是。在本文中，我们强调了潜在的进化意义，这种种间差异在颌骨发育和进化。(C)2003 Wiley-Liss，Inc.
Cranial neural crest cells are a multipotent, migratory population that generates most of the cartilage, bone, connective tissue and peripheral nervous system in the vertebrate head. Proper neural crest cell patterning is essential for normal craniofacial morphogenesis and is highly conserved among vertebrates. Neural crest cell patterning is intimately connected to the early segmentation of the neural tube, such that neural crest cells migrate in discrete segregated streams. Recent advances in live embryo imaging have begun to reveal the complex behaviour of neural crest cells which involve intricate cell-cell and cell-environment interactions. Despite the overall similarity in neural crest cell migration between distinct vertebrates species there are important mechanistic differences. Apoptosis for example, is important for neural crest cell patterning in chick embryos but not in mouse, frog or fish embryos. In this paper we highlight the potential evolutionary significance of such interspecies differences in jaw development and evolution. (C) 2003 Wiley-Liss, Inc.