The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer.
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer.
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DOI：
10.1007/s10555-016-9649-6
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发表时间：
2016-12
影响因子：
9.2
通讯作者：
Hung, Mien-Chie
中科院分区：
文献类型：
--
作者：
Hsu, Jennifer L.;Hung, Mien-Chie
乳腺癌影响大约八分之一的女性，据估计，2016年美国将有超过246，660名女性被诊断患有乳腺癌。由于早期发现和治疗的改善，乳腺癌死亡率在过去二十年中有所下降。在过去的几年里，有越来越多的证据表明受体酪氨酸激酶（RTK）在肿瘤发生和发展中的重要作用，针对RTK的靶向治疗已经开发出来，在临床试验中进行了评估，并批准用于许多癌症类型，包括乳腺癌。然而，并非所有的乳腺癌都是相同的，这一点可以从疾病的多种亚型中得到证明，其中一些亚型比其他亚型更具侵袭性，对不同类型的药物表现出不同的治疗反应。此外，除了来自细胞表面的典型信号传导之外，许多RTK可以被运输到各种亚细胞区室，例如多泡体和细胞核，在那里它们执行关键的细胞功能，例如细胞增殖、DNA复制和修复以及治疗抗性。在这篇综述中，我们提供了一个简短的总结在乳腺癌中的作用，选择一些RTK和描述的耐药机制。
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660 women in the United States will be diagnosed with breast cancer in 2016. Breast cancer mortality has decline over the last two decades due to early detection and improved treatment. Over the last few years, there is mounting evidence to demonstrate the prominent role of receptor tyrosine kinases (RTKs) in tumor initiation and progression, and targeted therapies against the RTKs have been developed, evaluated in clinical trials, and approved for many cancer types, including breast cancer. However, not all breast cancers are the same as evidenced by the multiple subtypes of the disease, with some more aggressive than others, showing differential treatment response to different types of drugs. Moreover, in addition to canonical signaling from the cell surface, many RTKs can be trafficked to various subcellular compartments, such as the multivesicular body and nucleus, where they carry out critical cellular functions, such as cell proliferation, DNA replication and repair, and therapeutic resistance. In this review, we provide a brief summary on the role of a selected number of RTKs in breast cancer and describe some mechanisms of resistance.
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影响因子：
50.3
作者：
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通讯作者：
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影响因子：
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