Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: A prospective, randomized study
Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: A prospective, randomized study
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DOI：
10.1023/a:1009474307376
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发表时间：
2000-03-01
影响因子：
3.1
通讯作者：
Chen, CL
中科院分区：
文献类型：
--
作者：
Hsieh, YY;Tsai, HD;Chen, CL
目的：探讨阿司匹林对子宫内膜较薄不孕症患者的治疗效果。方法：将子宫内膜厚度小于或等于8 mm的不孕症患者随机分为阿司匹林组和非阿司匹林组。结果：服用阿司匹林组114例，非阿司匹林组122例，子宫动脉、螺旋动脉和卵巢优势卵泡的搏动指数(PI)、阻力指数(RI)及妊娠率分别为46.5%和26.2%，妊娠率分别为18.4%和9.0%。两组子宫内膜厚度及子宫动脉、螺旋动脉、卵巢优势卵泡的PI/RI值差异无统计学意义。结论：阿司匹林治疗子宫内膜较薄的患者妊娠率较高，子宫内膜形态较好。阿司匹林治疗不能明显增加子宫内膜厚度和子宫卵巢血流阻力。
Purpose: The objective was to evaluate the effect of aspirin on infertile women with thin endometrium.Methods: Patients who had thin endometrium (less than or equal to 8 mm) and intrauterine insemination were divided into the aspirin and nonaspirin groups. Endometrial pattern (trilaminar and nontrilaminar) and thickness, the pulsatility index (PI) and resistance index (RI) of the uterine artery, spiral artery and ovarian dominant follicles, and pregnancy rates of both groups were measured.Results: A total of 114 and 122 women were included in the aspirin and nonaspirin groups, respectively There were significantly higher percentages of trilaminar endometrium (46.5% vs. 26.2%) and pregnancy rate (18.4% vs. 9.0%) after aspirin therapy. There was nonsignificant difference in the endometrial thickness, and PI/RI values of the uterine artery, spiral artery, and ovarian dominant follicle between both groups.Conclusions: Higher pregnancy rate and better endometrial pattern were achieved in patients with thin endometrium after aspirin administration. Aspirin therapy could not significantly increase the endometrial thickness and the resistance of uterine and ovarian flow.