Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.
Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.
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核非磷酸化β-catenin在急性髓样白血病和骨髓增生综合征中的临床意义。
DOI：
10.1111/j.1365-2141.2007.06914.x
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发表时间：
2008-02
影响因子：
6.5
通讯作者：
Naoe, Tomoki
中科院分区：
文献类型：
--
作者：
Xu, Jinglan;Suzuki, Momoko;Niwa, Yousuke;Hiraga, Junji;Nagasaka, Tetsuro;Ito, Masafumi;Nakamura, Shigeo;Tomita, Akihiro;Abe, Akihiro;Kiyoi, Hitoshi;Kinoshita, Tomohiro;Naoe, Tomoki
关键词：
Wnt信号激活典型通路并诱导非磷酸化β -连环蛋白（NPBC）在细胞核中的积累。尽管这一途径在造血干细胞的维持和肿瘤发生中发挥着重要作用，但核NPBC在恶性造血中的意义尚不清楚。本研究分别检测了54例和44例新发急性髓性白血病（AML）和骨髓增生异常综合征（MDS）患者骨髓标本中核NPBC的表达。用抗npbc抗体免疫组化染色，22例AML和18例MDS的细胞核分别呈阳性。核NPBC染色与AML亚型（M6和M7）、完全缓解率低、预后差相关。当使用国际预后评分系统（IPSS）诊断MDS、−7/−7q和复杂核型时，核NPBC也与高分相关。这些结果提示，通过免疫组织化学原位检测核NPBC可以为AML和MDS的发病机制和预后提供新的见解。
Wnt signaling activates the canonical pathway and induces the accumulation of non-phosphorylated beta-catenin (NPBC) in the nucleus. Although this pathway plays an important role in the maintenance of haematopoietic stem cells as well as in oncogenesis, the significance of nuclear NPBC remains unclear in malignant haematopoiesis. This study examined the expression of nuclear NPBC in bone marrow specimens from 54 and 44 patients with de novo acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS), respectively. On immunohistochemistry with an anti-NPBC antibody, the nuclei were positively stained in 22 and 18 of AML and MDS specimens, respectively. Staining of nuclear NPBC was associated with AML subtypes (M6 and M7), low complete remission (CR) rate, and poor prognosis. Nuclear NPBC was also associated with a high score when using the International Prognostic Scoring System (IPSS) for MDS and with −7/−7q and complex karyotypes. These findings suggest that in situ detection of nuclear NPBC by immunohistochemistry could provide new insights into the pathogenesis and prognosis of AML and MDS.
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影响因子：
158.5
作者：
Jamieson, CHM;Ailles, LE;Weissman, IL
通讯作者：
Weissman, IL
影响因子：
20.3
作者：
Austin, TW;Solar, GP;Matthews, W
通讯作者：
Matthews, W
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15.9
作者：
Conacci-Sorrell, M;Zhurinsky, J;Ben-Ze'ev, A
通讯作者：
Ben-Ze'ev, A
影响因子：
64.8
作者：
Reya, T;Duncan, AW;Weissman, IL
通讯作者：
Weissman, IL
影响因子：
56.9
作者：
He, TC;Sparks, AB;Kinzler, KW
通讯作者：
Kinzler, KW