Rapid testosterone-induced growth of the medial preoptic nucleus in male canaries.
Rapid testosterone-induced growth of the medial preoptic nucleus in male canaries.
复制标题
睾丸激素诱导雄性金丝雀内侧视前核的快速生长。
DOI：
10.1016/j.physbeh.2019.02.007
复制
发表时间：
2019
影响因子：
2.9
通讯作者：
Balthazart,Jacques
中科院分区：
文献类型：
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作者：
Shevchouk,OlesyaT;Ball,GregoryF;Cornil,CharlotteA;Balthazart,Jacques
睾丸激素会在几天内激活被阉割的雄性鸣禽的歌唱，但完整的歌唱质量仅在几周后才形成。内侧视前核（POM）的损伤会抑制，而立体定位睾酮植入该核会增加歌唱频率，表明该位点在歌唱动机的调节中起着关键作用。歌曲控制系统中的睾酮作用与控制歌曲质量同时起作用。因此，全身睾酮会在雌性金丝雀中 1-2 天内增加 POM 体积，而鸣叫控制核体积的增加至少需要 2 周。目前的研究测试了睾酮作用是否与男性潜伏期的类似差异相关。光敏去势雄性金丝雀被植入充满睾酮的 Silastic™ 植入物，对照去势者则接受空植入物，同时光周期从短日照切换为长日照。两天后，从所有受试者身上采集了大脑。睾酮治疗组的血浆睾酮水平升高，而对照组则没有升高。 HVC 体积未受影响，但睾酮显着增加了 POM 体积，如通过密集的芳香酶免疫反应性神经元群、这些神经元的数量和体细胞面积以及它们在 POM 中覆盖的分数面积所确定的。先前实验中接受睾酮治疗的雌性在相似条件下的 POM 体积较小，表明存在可能影响歌唱行为的稳定性别差异。因此，睾酮在两天内诱导雄性 POM 生长并在该核中表达芳香酶，而不影响 HVC 大小，这进一步支持了睾酮通过其在 POM 中的作用增加歌唱动机的观点。
Testosterone activates singing within days in castrated male songbirds but full song quality only develops after a few weeks. Lesions of the medial preoptic nucleus (POM) inhibit while stereotaxic testosterone implants into this nucleus increase singing rate suggesting that this site plays a key role in the regulation of singing motivation. Testosterone action in the song control system works in parallel to control song quality. Accordingly, systemic testosterone increases POM volume within 1–2 days in female canaries, while the increase in volume of song control nuclei takes at least 2 weeks. The current study tested whether testosterone action is associated with similar differences in latencies in males. Photosensitive castrated male canaries were implanted with testosterone-filled Silastic™ implants and control castrates received empty implants, while simultaneously the photoperiod was switched from short- to long-days. Brains were collected from all subjects two days later. Plasma testosterone was elevated in testosterone-treated but not in controls. HVC volumes were not affected, but testosterone significantly increased the POM volume as identified by the dense group of aromatase-immunoreactive neurons, the number and somal area of these neurons and the fractional area they cover in POM. Testosterone-treated females from a previous experiment had a smaller POM volume in similar conditions suggesting the existence of a stable sex difference potentially affecting singing behavior. Thus testosterone induces male POM growth and aromatase expression in this nucleus within two days without affecting HVC size, further supporting the notion that testosterone increases singing motivation via its action in POM.
影响因子：
64.8
作者：
通讯作者：
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