Preparation of biomimetic catechol-based gold nanoparticles with superior stability
Preparation of biomimetic catechol-based gold nanoparticles with superior stability
复制标题
具有优异稳定性的仿生儿茶酚基金纳米颗粒的制备
DOI：
10.1016/j.matlet.2019.06.094
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发表时间：
2019
影响因子：
3
通讯作者：
Li Fan
中科院分区：
文献类型：
--
作者：
Zhao Liman;Yang Zechuan;Li Yanchun;Shi Tongfei;Pei Danfeng;Li Fan
合成了以聚多巴胺甲基丙烯酰胺-共聚乳酸氨基甲基丙烯酸乙酯（PDMA-co-PLAMA）为基础的仿生糖共聚物配体，用于有效还原金离子并锚定在金纳米粒子表面制备修饰金纳米粒子的糖共聚物（Gly@AuNPs）。Gly@AuNPs的制备和稳定是一步完成的，不需要传统的含硫醇聚合物来稳定aunp。结果表明，Gly@AuNPs在高盐浓度（500 mM NaCl）和不同pH条件下具有较长的稳定性。这些稳定的Gly@AuNPs可以为靶向癌症成像和光热治疗的应用提供有用的信息。
Biomimetic glycopolymers poly(dopamine methacrylamide-co-lactobionamidoethyl methacrylate) (PDMA-co-PLAMA) based ligand was synthesized, used to effectively reduce the gold ions and anchored on the surface of gold nanoparticles to prepare the glycopolymers modified gold nanoparticles (Gly@AuNPs). The Gly@AuNPs were prepared and stabilized in one step, which did not require classical thiol-containing polymer to stabilize AuNPs. The Gly@AuNPs were found to be highly stable at high salt concentrations (500 mM NaCl) and different pH conditions over a long time. These stable Gly@AuNPs could provide useful information in applications of targeted cancer imaging and photothermal therapy.