Clinical significance of circulating tumor cells in blood from patients with gastric cancer.
Clinical significance of circulating tumor cells in blood from patients with gastric cancer.
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DOI：
10.1002/ags3.12005
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发表时间：
2017-04
影响因子：
2.7
通讯作者：
Natsugoe S
中科院分区：
文献类型：
--
作者：
Arigami T;Uenosono Y;Yanagita S;Okubo K;Kijima T;Matsushita D;Amatatsu M;Kurahara H;Maemura K;Natsugoe S
循环肿瘤细胞（CTC）作为检测隐匿性肿瘤、预测治疗反应和复发以及监测包括胃癌在内的各种恶性肿瘤患者的术后复发的靶点已受到关注。分子诊断工具的最新进展有助于CTC检测的高灵敏度和特异性。CTC的发生率在不同研究中存在显著差异。然而，已报告CTC阳性与胃癌患者中众所周知的预后临床病理学因素（包括肿瘤浸润深度、淋巴结转移、分期以及淋巴和静脉浸润）之间存在密切关系。根据大多数关于CTC临床影响的研究，CTC的存在对胃癌患者的预后有负面影响。此外，基于Meta分析的CTC研究证明了其作为不良预后指标的重要性。在临床管理中，使用液体活检对CTC进行治疗前和治疗后监测可能有助于早期发现亚临床患者或疾病复发，预测肿瘤进展以及辅助化疗的管理控制。虽然其功能特性尚不清楚，但CTC的分子特征分析可能有助于开发有效抑制晚期胃癌患者肿瘤进展的个性化治疗。本文就CTC作为胃癌患者血液标志物和治疗靶点的临床意义作一综述。
Circulating tumor cells (CTC) have been focused on as a target for detecting occult tumors, predicting therapeutic responses and prognoses, and monitoring postoperative recurrence in the clinical management of patients with various malignancies, including gastric cancer. Recent advances in molecular diagnostic tools have contributed to high sensitivity and specificity for the detection of CTC. A conspicuous disparity exists in the incidence of CTC among studies. However, a close relationship has been reported between positivity for CTC and well‐known prognostic clinicopathological factors including depth of tumor invasion, lymph node metastasis, stage, and lymphatic and venous invasion in patients with gastric cancer. According to most studies published on the clinical impact of CTC, the presence of CTC negatively affects the prognosis of patients with gastric cancer. Moreover, the study of CTC based on a meta‐analysis demonstrated their importance as a poor prognostic indicator. In clinical management, pre‐ and post‐therapeutic monitoring of CTC using liquid biopsy may be useful for early detection of subclinical patients or disease recurrence, prediction of tumor progression, and administrative control of adjuvant chemotherapy. Although their functional properties remain unclear, molecular profiling of CTC may contribute to the development of personalized treatment that effectively inhibits tumor progression in patients with advanced gastric cancer. We herein review the clinical significance of CTC as a promising blood marker and therapeutic target in patients with gastric cancer.