Regulation of dynamin by nucleoside diphosphate kinase
Regulation of dynamin by nucleoside diphosphate kinase
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DOI：
10.1023/a:1023441806530
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发表时间：
2003-02-01
影响因子：
3
通讯作者：
Ramaswami, M
中科院分区：
文献类型：
--
作者：
Narayanan, R;Ramaswami, M
核苷二磷酸激酶（NDP）是多种细胞功能所必需的，包括细胞生长、运动和分化，其缺失与肿瘤转移等病理有关。最近的一项研究揭示了NDP激酶作为动力蛋白（一种内吞所必需的GTPase）的正调节因子的一种以前未知的功能。在这篇综述中，我们描述了NDP激酶功能对内吞作用至关重要的证据，并详细阐述了NDP激酶调节动力蛋白的机制。最近记录的内吞作用和细胞信号传导之间的相互作用揭示了对癌症潜在机制的新见解。在这种情况下，我们讨论了NDP激酶和动力蛋白相互作用对肿瘤抑制的可能相关性。
Nucleoside diphosphate (NDP) kinase is required for multiple cellular functions, including cell growth, motility, and differentiation, and its loss is associated with pathologies including tumor metastasis. A recent study has revealed a previously unknown function for NDP kinase as positive regulator of dynamin, a GTPase essential for endocytosis. In this review we describe the evidence that NDP kinase function is essential for endocytosis and also elaborate on a mechanism for NDP kinase regulation of dynamin. Recently documented interactions between endocytosis and cell signaling have revealed new insights into potential mechanisms of cancer. In this context, we discuss the possible relevance of NDP kinase and dynamin interaction for tumor suppression.