EVIDENCE FOR LACTATE UTILIZATION FOR FETAL LUNG GLYCOGEN-SYNTHESIS
EVIDENCE FOR LACTATE UTILIZATION FOR FETAL LUNG GLYCOGEN-SYNTHESIS
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DOI：
10.1016/0006-291x(87)91335-0
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发表时间：
1987-05-29
影响因子：
3.1
通讯作者：
BROWN, DJ
中科院分区：
文献类型：
--
作者：
ENGLE, MJ;DOOLEY, M;BROWN, DJ
使用妊娠23天动物的胎兔肺研究乳酸作为胎肺糖原合成底物的潜在作用。胎儿乳酸脱氢酶活性约为成人肺中发现的两倍，而磷酸烯醇式丙酮酸羧激酶的活性升高超过成人值的四倍。丙酮酸羧化酶活性在胎儿和成人肺中相似。在器官培养中使用胎肺外植体的研究表明，葡萄糖和乳酸的存在可能是发育中的胎肺中糖原积累所必需的。这些数据支持乳酸是胎儿肺糖原的重要前体的假设。
Fetal rabbit lungs from 23 day gestation animals were used to investigate the potential role of lactate as a substrate for fetal lung glycogen synthesis. Fetal lactate dehydrogenase activity was approximately twice that found in the adult lung, while the activity of phosphoenolpyruvate carboxykinase was elevated fourfold over the adult value. Pyruvate carboxylase activities were similar in both fetal and adult lungs. Studies employing fetal lung explants in organ culture indicated that the presence of both glucose and lactate may be necessary for glycogen accumulation in the developing fetal lung. These data support the hypothesis that lactate is an important precursor for fetal lung glycogen.