Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents
Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents
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DOI：
10.1515/jpem-2012-0131
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发表时间：
2012-08-01
影响因子：
1.4
通讯作者：
Spiliotis, Bessie E.
中科院分区：
文献类型：
--
作者：
Partsalaki, Ioanna;Karvela, Alexia;Spiliotis, Bessie E.
背景资料：碳水化合物限制的影响目的：比较生酮饮食和低热量饮食在肥胖儿童和青少年中的疗效和代谢影响。受试者：58名肥胖受试者接受两种饮食中的一种饮食6个月。人体测量、身体组成、口服葡萄糖/胰岛素耐量试验、血脂谱、高分子量（HMW）脂联素、全身胰岛素敏感性指数（WBISI），结果：两组均显著降低了体重、脂肪量、腰围、空腹胰岛素和HOMA-IR（生酮组p=0.009，低热量组p =0.014），但生酮组差异更大。两组均显着增加WBISI，但只有生酮组显着增加HMW脂联素（p=0.025）。结论：生酮饮食比低热量饮食在体重减轻和代谢参数方面显示出更明显的改善，可能是儿童减肥的可行且安全的替代方案。
Background: The effects of carbohydrate-restricted (ketogenic) diets on metabolic parameters in children have been incompletely assessed.Objective: To compare the efficacy and metabolic impact of ketogenic and hypocaloric diets in obese children and adolescents.Subjects: Fifty-eight obese subjects were placed on one of the two diets for 6 months.Methods: Anthropometric measurements, body composition, oral glucose/insulin tolerance test, lipidemic profile, high molecular weight (HMW) adiponectin, whole-body insulin sensitivity index (WBISI), and homeostatic model assessment-insulin resistance (HOMA-IR) were determined before and after each diet.Results: Both groups significantly reduced their weight, fat mass, waist circumference, fasting insulin, and HOMA-IR (p=0.009 for ketogenic and p=0.014 for hypocaloric), but the differences were greater in the ketogenic group. Both groups increased WBISI significantly, but only the ketogenic group increased HMW adiponectin significantly (p=0.025).Conclusions: The ketogenic diet revealed more pronounced improvements in weight loss and metabolic parameters than the hypocaloric diet and may be a feasible and safe alternative for children's weight loss.