Thermoplastic Electrode Arrays in Electrochemical Paper-Based Analytical Devices
Thermoplastic Electrode Arrays in Electrochemical Paper-Based Analytical Devices
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DOI：
10.1021/acs.analchem.8b05218
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发表时间：
2019-02-05
影响因子：
7.4
通讯作者：
Henry, Charles S.
中科院分区：
文献类型：
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作者：
Noviana, Eka;Klunder, Kevin J.;Henry, Charles S.
电化学纸基分析装置（ePAD）由于其低成本和简单的制造而作为传统台式方法的替代品已经引起了极大的兴趣。从历史上看，ePAD几乎完全依赖于单电极检测，限制了多电极可实现的灵敏度和选择性的潜在增益。在本文中，我们描述了将热塑性电极（TPE）阵列结合到流动ePAD中。准稳态流动仅由通过扇形纸装置的毛细管作用产生。使用简单的溶剂辅助方法用廉价的材料（即，石墨和热塑性粘合剂）。这些电极可以用作可单独寻址的检测器的阵列或连接为叉指电极阵列。通过扫描电镜、光学轮廓仪和循环伏安法对热塑性弹性体进行表征。计时电流法用于表征基于流动的TPE-ePAD。痕量检测的二茂铁复合物（FcTMA+），通过代收集实验证明，达到0.32 pmol的检测限。这些含有ePAD的TPE阵列显示出作为一种快速、灵敏和低成本传感器的巨大潜力，适用于需求点（PON）应用。
Electrochemical paper-based analytical devices (ePADs) have garnered significant interest as an alternative to traditional benchtop methods due to their low cost and simple fabrication. Historically, ePADs have relied almost exclusively on single electrode detection, limiting potential gains in sensitivity and selectivity achievable with multiple electrodes. Herein we describe incorporation of thermoplastic electrode (TPE) arrays into flow ePADs. Quasi-steady flow was solely generated by capillary action through a fan-shaped paper device. The electrode arrays were fabricated using a simple solvent-assisted method with inexpensive materials (i.e., graphite and thermoplastic binder). These electrodes can be employed as an array of individually addressable detectors or connected as an interdigitated electrode array. The TPEs were characterized through SEM, optical profilometry and cyclic voltammetry. Chronoamperometry was used to characterize the flow-based TPE-ePADs. Trace detection of a ferrocene complex (FcTMA+) was demonstrated through generation-collection experiments, achieving a limit of detection of 0.32 pmol. These TPE arrays containing ePADs show great promise as a rapid, sensitive, and low-cost sensor for point-of-need (PON) applications.