The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts.
The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts.
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DOI：
10.1530/eje-08-0056
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发表时间：
2008-07
影响因子：
5.8
通讯作者：
Smith GD
中科院分区：
文献类型：
--
作者：
Lewis SJ;Lawlor DA;Nordestgaard BG;Tybjaerg-Hansen A;Ebrahim S;Zacho J;Ness A;Leary S;Smith GD
流行病学研究表明，低叶酸水平与高体重指数（BMI）有关。这些发现具有潜在的重要健康影响，需要进一步调查，以确定是否存在因果关系以及这种关系的方向。亚甲基四氢叶酸还原酶（MTHFR）C677T TT基因型与叶酸利用率降低相关，可能是测量叶酸水平的替代品。我们试图确定MTHFR C677T基因型是否与肥胖相关。我们对来自英国和丹麦的三项纵向研究的四个人群进行了研究，其中沿着肥胖测量获得了用于基因分型的DNA。我们的研究对象来自英国女性心脏和健康研究（BWHHS），雅芳父母和儿童纵向研究（两个人群：母亲和儿童）和哥本哈根城市心脏研究。我们按人群分别进行分析，然后结合相似人群进行荟萃分析。BWHHS的初步研究结果表明，TT基因型可能与BMI≥30的肥胖风险增加有关，但在该队列中未发现与BMI或中心性肥胖相关。在我们的其他队列中，这种基因型与肥胖无关。我们的研究结果表明，最初的阳性结果与肥胖的BWHHS是一个偶然的发现。我们的研究结果不支持低叶酸对肥胖的因果关系。
Epidemiological studies have shown that low folate levels are associated with a high body mass index (BMI). These findings have potentially important health implications and warrant further investigation to determine whether a causal relationship exists and the direction of this relationship. The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels. We sought to determine whether MTHFR C677T genotype was associated with obesity. We carried out our study on four populations from three longitudinal studies based in the UK and Denmark in which DNA for genotyping was obtained along with measures of obesity. Our subjects were taken from the British Women's Heart and Health Study (BWHHS), the Avon Longitudinal Study of Parents and Children (two populations: mothers and children) and the Copenhagen City Heart Study. We performed analyses separately by population, and then carried out a meta-analysis, combining similar populations. Initial findings in the BWHHS suggested that the TT genotype may be associated with an increased risk of obesity BMI≥30, however, no association was found with BMI or central adiposity in this cohort. This genotype was not associated with obesity in our other cohorts. Our results suggest that the initial positive finding with obesity in the BWHHS was a chance finding. Our findings do not support a causal effect of low folate on obesity.