INFLUENCE OF GENETIC OBESITY ON TISSUE CONCENTRATIONS OF ZINC, COPPER, MANGANESE AND IRON IN MICE
INFLUENCE OF GENETIC OBESITY ON TISSUE CONCENTRATIONS OF ZINC, COPPER, MANGANESE AND IRON IN MICE
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DOI：
10.1093/jn/116.8.1432
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发表时间：
1986-08-01
影响因子：
4.2
通讯作者：
SMITH, JC
中科院分区：
文献类型：
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作者：
KENNEDY, ML;FAILLA, ML;SMITH, JC
C57BL/6J瘦肉型(+/？)不同组织中4种必需微量元素含量(微克/克干重)并测定肥胖(ob/ob)小鼠。在22周龄时，肥胖小鼠的肝脏、股骨、小肠和肌肉中的锌浓度低于瘦小鼠。成年肥胖小鼠肝脏、股骨、小肠、肌肉和睾丸中的铜含量，肝脏、股骨、肌肉和血浆中的铁含量，以及肝脏、股骨和小肠中的锰含量也显著低于年龄匹配的瘦小鼠组织中的含量。考虑到肥胖小鼠和瘦小鼠肝脏中性脂类含量的不同，肥胖小鼠肝脏中锌、铜和锰的浓度也低于瘦小鼠。与成年肥胖小鼠组织中微量金属浓度降低的趋势相反，成年肥胖小鼠的血浆锌、铜水平和铜蓝蛋白活性高于瘦对照组。遗传性肥胖对组织中痕量金属浓度的影响是相似的。遗传性肥胖对组织中微量金属浓度的影响在雄性和雌性小鼠中是相似的。年轻(5-6周)肥胖小鼠的几个组织中的痕量金属浓度也低于年龄匹配的瘦小鼠，尽管差异不像成年小鼠那么大。这些数据表明，遗传性肥胖(ob/ob)小鼠的慢性肥胖与组织中几种无机微量营养素的浓度较低(但不一定是总量)有关。讨论了慢性肥胖改变这些痕量金属的营养需求的可能性。
The concentrations (micrograms/gram dry wt) of four essential trace metals in various tissues from C57BL/6J lean (+/?) and obese (ob/ob) mice were determined. Lower concentrations of zinc were found in liver, femur, small intestine and muscle from obese mice than in those from lean mice at 22 wk of age. The concentrations of copper in liver, femur, small intestine, muscle and testes, iron in liver, femur, muscle and plasma, and manganese in liver, femur and small intestine from adult obese mice were also significantly below the concentrations present in tissues from age-matched lean mice. Hepatic concentrations of zinc, copper and manganese in obese mice were also lower than those in lean mice when the different amounts of neutral lipid in obese and lean liver were considered. In contrast with the trend towards lower concentrations of trace metals in tissues from adult obese mice, plasma zinc and copper levels and ceruloplasmin activity were higher in adult obese mice than in lean controls. The effect of genetic obesity on tissue trace metals concentrations was similar. The effect of genetic obesity on tissue trace metals concentrations was similar in male and female mice. Several tissues from young (5-6 wk of age) obese mice also had lower concentrations of the trace metals than age-matched lean mice, although the differences were not as a great as in adults. These data demonstrate that chronic obesity in the genetically obese (ob/ob) mouse is associated with lower concentrations, but not necessarily lower total quantities, of several inorganic micronutrients in tissues. The possibility that chronic obesity alters the nutritionalrequirements for these trace metals is discussed.