Multiple-Gestation Pregnancies after Assisted Reproductive Technology Treatment: Population Trends and Future Directions
Multiple-Gestation Pregnancies after Assisted Reproductive Technology Treatment: Population Trends and Future Directions
复制标题
辅助生殖技术治疗后的多胎妊娠：人口趋势和未来方向
DOI：
10.2217/17455057.3.3.301
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
L. Schieve
中科院分区：
文献类型：
--
作者：
L. Schieve
辅助生殖技术（ART）治疗，如体外受精，已使全世界许多夫妇受益。然而，目前实行的抗逆转录病毒疗法通常移植至少两个胚胎，对多胎妊娠和伴随的严重母婴健康后遗症构成相当大的风险。虽然限制移植胚胎的数量似乎是一个直截了当的解决方案，但单胚胎移植的治疗很少。造成这种情况的可能原因包括：考虑到高昂的费用和缺乏保险覆盖，患者和提供者希望在一次治疗中最大限度地提高成功的机会，（有时是错误的）认为移植更多的胚胎会增加怀孕的机会，以及一些接受抗逆转录病毒治疗的妇女更喜欢多胎。尽管最近美国和欧洲基于人口的数据表明，移植的胚胎数量正在减少，但抗逆转录病毒技术的多胎出生率仍然很高。需要全面的患者教育工作和对单胚胎移植疗效的持续研究。
Assisted reproductive technology (ART) treatments, such as in vitro fertilization, have benefited many couples worldwide. However, ART as currently practiced, with the usual transfer of at least two embryos, poses sizable risks for multiple-gestation pregnancy and accompanying serious maternal and child health sequelae. While limiting the number of embryos transferred would appear a straightforward solution, treatments with single-embryo transfer are rare. Likely reasons for this include patient and provider desires to maximize the chance for success in a single treatment given the high cost and lack of insurance coverage, the (sometimes mistaken) belief that transferring more embryos will increase the chance for pregnancy, and the preference for multiple births among some women undergoing ART. Although recent population-based data in the USA and Europe suggest the number of embryos transferred is decreasing, the ART multiple-birth rate remains high. Comprehensive patient-education efforts and continued research on the efficacy of single-embryo transfer are needed.