Functions of the SLC36 transporter Pathetic in growth control.
Functions of the SLC36 transporter Pathetic in growth control.
复制标题
SLC36 转运蛋白在生长控制中的功能可悲。
DOI：
10.1080/19336934.2015.1129089
复制
发表时间：
2015
期刊：
影响因子：
1.2
通讯作者：
Parrish,JayZ
中科院分区：
文献类型：
--
作者：
Lin,Wen-Yang;Williams,ClaireR;Yan,Connie;Parrish,JayZ
Neurons exhibit extreme diversity in size, but whether large neurons have specialized mechanisms to support their growth is largely unknown. Recently, we identified the SLC36 transporter Pathetic (Path) as a factor required for extreme dendrite growth in neurons. Path is broadly expressed, but only neurons with large dendrite arbors or small neurons that are forced to grow large requirepathfor their growth. To gain insight into the basis of growth control bypath, we generated additional alleles ofpathand further examined the apparent specificity of growth defects inpathmutants. Here, we confirm our prior finding that loss ofpathfunction imposes an upper limit on neuron growth, and additionally report thatpathlikely limits overall neurite length rather than dendrite length alone. Using a GFP knock-in allele ofpath, we identify additional tissues wherepathlikely functions in nutrient sensing and possibly growth control. Finally, we demonstrate thatpathregulates translational capacity in a cell type that does not normally requirepathfor growth, suggesting thatpathmay confer robustness on growth programs by buffering translational output. Altogether, these studies suggest that Path is a nutrient sensor with widespread function in Drosophila.
