Standardized Uptake Values in the Primary Lesions of Non-Small-Cell Lung Cancer in FDG-PET/CT Can Predict Regional Lymph Node Metastases
Standardized Uptake Values in the Primary Lesions of Non-Small-Cell Lung Cancer in FDG-PET/CT Can Predict Regional Lymph Node Metastases
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DOI：
10.1245/s10434-015-4564-6
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发表时间：
2015-12-01
影响因子：
3.7
通讯作者：
Takagi, Masayuki
中科院分区：
文献类型：
--
作者：
Nakamura, Haruhiko;Saji, Hisashi;Takagi, Masayuki
目的.检查了F-18-氟脱氧葡萄糖正电子发射断层扫描联合计算机断层扫描（FDG-PET/CT）中非小细胞肺癌原发灶的最大标准化摄取值（SUVmax），以及肿瘤的显微镜局部范围，以制定可靠的标准来确定肺叶切除的候选者。方法。我们回顾性分析了209例接受肺叶切除术、双叶切除术或全肺切除术联合系统淋巴结清扫术的患者。术前SUVmax在原发性病变，显微镜下淋巴，静脉，胸膜浸润以及淋巴结转移的切除标本进行了检查。受试者操作特征分析用于预测淋巴结转移的最佳临界值。受试者操作特征分析显示，SUVmax和肿瘤大小的曲线下面积分别为0.693和0.545，表明SUVmax预测淋巴结转移的优效性，临界值为2.9。当肿瘤
Purpose. Maximum standardized uptake values (SUVmax) at the primary lesions of non-small-cell lung cancer in F-18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT), and the microscopic local extension of tumors were examined to develop reliable criteria to determine candidates for sublobar resection.Methods. We retrospectively analyzed 209 patients who underwent lobectomy, bilobectomy, or pneumonectomy with systematic lymph node dissection. Preoperative SUVmax at the primary lesion, microscopic lymphatic, venous, and pleural invasion in addition to lymph node metastases in the resected specimens were examined. Receiver operating characteristic analyses were used to predict an optimal cutoff for lymph node metastases.Results. With receiver operating characteristic analysis, the areas under the curve for SUVmax and tumor size were 0.693 and 0.545, respectively, suggesting SUVmax superiority for prediction of lymph node metastases with a cutoff of 2.9. When a tumor was