Variability in the fatty acid composition of wax esters from vernix caseosa and its possible relation to sebaceous gland activity.
Variability in the fatty acid composition of wax esters from vernix caseosa and its possible relation to sebaceous gland activity.
复制标题
酪脂蜡酯脂肪酸组成的变化及其与皮脂腺活性的可能关系。
DOI：
10.1111/1523-1747.ep12507228
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Downing,DT
中科院分区：
文献类型：
--
作者：
Stewart,ME;Quinn,MA;Downing,DT
本文测量了21例足月婴儿皮脂中蜡酯/固醇酯（WE/SE）的比值。男性的平均WE/SE比是女性的两倍，这表明男性的平均胎儿皮脂生成率更高，但个体值差异很大，性别之间存在相当大的重叠。从21份皮脂腺脂质样品中的6份中分离出蜡酯（一种仅由皮脂腺产生的脂质）并分析其脂肪酸组成。原始脂质样品的WE/SE比与iso和anteiso支链饱和脂肪酸和Δ9-type单不饱和脂肪酸的百分比呈负相关。主要的Δ9-type单不饱和脂肪酸的百分比值，绘制为WE/SE比率的函数，下降到一条曲线附近，如果有限数量的Δ9-type单不饱和脂肪酸可用于皮脂合成，并被不同数量的Δ6-type单不饱和脂肪酸稀释，Δ6-type单不饱和脂肪酸的数量与皮脂腺合成的蜡酯的数量成正比。结果表明，皮脂生成速率可能是皮脂蜡酯中Δ9-type单不饱和脂肪酸百分比的唯一决定因素，也是iso和anteiso分支饱和脂肪酸百分比的部分决定因素。
Wax ester/sterol ester (WE/SE) ratios were measured in samples of vernix caseosa lipid obtained from 21 full-term infants. The mean WE/SE ratio was twice as high in males as in females, suggesting higher average fetal sebum production rates in males, but individual values varied widely and there was considerable overlap between the sexes.Wax esters (a class of lipid produced only by the sebaceous glands) were isolated from 6 of the 21 samples of vernix caseosa lipid and analyzed for fatty acid composition. The percentages of iso and anteiso branched saturated fatty acids and of Δ9-type monounsaturated fatty acids were found to be correlated negatively with the WE/SE ratios of the original lipid samples. Values for the percentages of the major Δ9-type monounsaturates, plotted as a function of WE/SE ratios, fell near a curve of the shape which would be expected if a limited quantity of Δ9-type monounsaturates were available for sebum synthesis, and were diluted with varying amounts of Δ6-type monounsaturates, the amount of the Δ6-type monounsaturates being proportional to the amount of wax esters synthesized by the sebaceous glands. The results suggested that the rate of sebum production may be the sole determinant of the percentage of Δ9-type monounsaturates in sebaceous wax esters and a partial determinant of the percentage of iso and anteiso branched saturates.