Aging of the subventricular zone neural stem cell niche.
Aging of the subventricular zone neural stem cell niche.
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DOI：
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发表时间：
2011
影响因子：
7.4
通讯作者：
J. Conover;Brett A. Shook
中科院分区：
文献类型：
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作者：
J. Conover;Brett A. Shook
成年哺乳动物前脑中活跃的室管膜下区神经干细胞生态位的持续存在支持其在新神经元的产生和产生细胞以在成年期修复中发挥作用中的持续作用。不幸的是，随着年龄的增长，利基开始恶化，损害这些功能。这种下降的原因尚不清楚。研究开始确定老化室管膜下区微环境的分子和生理变化。衰老研究的新启示将使我们能够更透彻地了解衰老大脑中哪些修复功能丢失，生态位消亡的进展以及治疗干预改善衰老大脑功能的可能性。
The persistence of an active subventricular zone neural stem cell niche in the adult mammalian forebrain supports its continued role in the production of new neurons and in generating cells to function in repair through adulthood. Unfortunately, with increasing age the niche begins to deteriorate, compromising these functions. The reasons for this decline are not clear. Studies are beginning to define the molecular and physiologic changes in the microenvironment of the aging subventricular zone niche. New revelations from aging studies will allow for a more thorough understanding of which reparative functions are lost in the aged brain, the progression of niche demise and the possibility for therauptic intervention to improve aging brain function.