Biarylpyrimidines: a new class of ligand for high-order DNA recognition
Biarylpyrimidines: a new class of ligand for high-order DNA recognition
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DOI：
10.1039/b301554h
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发表时间：
2003-01-01
影响因子：
4.9
通讯作者：
Wheelhouse, RT
中科院分区：
文献类型：
--
作者：
Murphy, PM;Phillips, VA;Wheelhouse, RT
带有ω-氨基烷基取代基的联芳基嘧啶已被设计为高阶DNA结构的配体：分光光度法、热和竞争平衡透析分析表明，将用于取代基连接的官能团从硫醚改变为酰胺，将结构结合偏好从三链体转换为四链体DNA;新的配体是无毒的，并且是人类端粒酶的温和抑制剂。
Biarylpyrimidines bearing omega-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.