Cell migration by swimming: Drosophila adipocytes as a new in vivo model of adhesion-independent motility.
Cell migration by swimming: Drosophila adipocytes as a new in vivo model of adhesion-independent motility.
复制标题
DOI：
10.1016/j.semcdb.2019.11.009
复制
发表时间：
2019-12
影响因子：
7.3
通讯作者：
Paul Martin;Will Wood;Anna Franz
中科院分区：
文献类型：
--
作者：
Paul Martin;Will Wood;Anna Franz
几种细胞谱系通过我们身体的发育和成年组织迁移，利用各种运动模式来适应它们在到达目的地的途中遇到的不同基质和环境。在这里，我们描述了一种新的粘附独立模式的单细胞运动所利用的果蝇体细胞-脊椎动物的脂肪细胞的等价物。像它们的人类对应物一样，这些大细胞以前被认为是不动的。然而，在果蝇中，脂肪体细胞似乎是能动的，并通过蠕动游动通过血淋巴以定向方式向伤口迁移。这种推进力是由皮层肌动球蛋白的波动产生的，这种波动沿着沿着细胞的长度向后传播。我们讨论了这种运动的游泳模式如何克服微观物体在流体中移动的物理限制，脂肪体细胞如何打开其他“运动机器”来堵塞到达的伤口，以及果蝇和其他生物体中的其他细胞谱系是否可以在某些情况下也采用游泳作为有效的迁移模式。
Several cell lineages migrate through the developing and adult tissues of our bodies utilising a variety of modes of motility to suit the different substrates and environments they encounter en route to their destinations. Here we describe a novel adhesion-independent mode of single cell locomotion utilised byDrosophilafat body cells – the equivalent of vertebrate adipocytes. Like their human counterpart, these large cells were previously presumed to be immotile. However, in theDrosophilapupa fat body cells appear to be motile and migrate in a directed way towards wounds by peristaltic swimming through the hemolymph. The propulsive force is generated from a wave of cortical actomyosin that travels rearwards along the length of the cell. We discuss how this swimming mode of motility overcomes the physical constraints of microscopic objects moving in fluids, how fat body cells switch on other “motility machinery” to plug the wound on arrival, and whether other cell lineages inDrosophilaand other organisms may, under certain circumstances, also adopt swimming as an effective mode of migration.