Comparison of Helicobacter pylori and H-heilmannii gastritis - Matched control study involving 404 patients
Comparison of Helicobacter pylori and H-heilmannii gastritis - Matched control study involving 404 patients
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DOI：
10.3109/00365529709025059
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发表时间：
1997-01-01
影响因子：
1.9
通讯作者：
Bethke, B
中科院分区：
文献类型：
--
作者：
Stolte, M;Kroher, G;Bethke, B
背景资料：由于Helicobacterheilmannii胃炎比H.pylori胃炎罕见得多，而且迄今为止还没有比较这两种胃炎的系统研究，我们进行了本研究，以探讨H.pylori胃炎与H.pylori胃炎之间可能的差异。heilmannii和H.幽门胃炎方法：对202例H. Heilmannii胃炎组和202例对照组H.对以下变量进行分级和比较：螺杆菌定植、慢性胃炎、胃炎活动性、再生上皮取代小窝上皮、粘液消耗、获得性粘膜相关淋巴组织（MALT）的频率和肠化生。结果：与H. pylori的弥漫性定植模式相反，H.海尔曼氏菌主要（91.2%）是局灶性的，并且大部分局限于胃窦（仅29.1%同时定植于体部）。所有胃炎变量的分级在H.海尔曼氏胃炎此外，肠上皮化生和获得性MALT在H患者中明显不常见。海尔曼感染H. Heilmannii胃炎通常与使用非甾体类抗炎药有关。在一例H. 7例胃粘膜相关淋巴组织淋巴瘤。幽门螺杆菌感染胃粘膜很少定植有海尔曼螺杆菌，主要局限于胃窦，在胃窦和胃体引起非常轻微的胃炎，这也可能是很少并发糜烂和溃疡的原因。是否观察到相对频繁的H. H.与H. pylori胃炎的诊断有待进一步研究。
Background: Since Helicobacter heilmannii gastritis is very much rarer than H, pylori gastritis, and no systematic studies comparing these two gastritides have so far been carried out, we undertook the present study to investigate possible differences between H. heilmannii and H. pylori gastritis. Methods: In 202 patients with H. heilmannii gastritis and 202 matched control patients with H. pylori gastritis and duodenal ulcer the following variables were graded and compared: Helicobacter colonization, chronicity of gastritis, activity of gastritis, replacement of foveolar epithelium by regenerative epithelium, mucus depletion, frequency of acquired mucosa-associated lymphoid tissue (MALT), and intestinal metaplasia. Results: In contrast to the diffuse pattern of colonization in the case of H, pylori, colonization with H. heilmannii is mainly (91.2%) focal and for the most part restricted to the antrum (only 29.1% concurrent colonization of the corpus). The gradings of all gastritis variables were statistically highly significantly milder in the case of H. heilmannii gastritis. In addition, intestinal metaplasia and acquired MALT were significantly less common in patients with H. heilmannii infection. The rare cases of erosions (n = 8) and ulcerations (n = 8) in H. heilmannii gastritis were usually associated with the use of non-steroidal antiinflammatory drugs. In a single case of H. heilmannii gastritis a concurrent gastric carcinoma and in seven cases a low-grade gastric MALT lymphoma were found. Conclusion: In contrast to H. pylori infection the rare colonization of the gastric mucosa with H, heilmannii, mainly circumscribed and mostly in the antrum, induces a very much milder form of gastritis in the antrum and corpus, which may also be the reason for the rarity of concurrent erosions and ulcers. Whether the observed relatively frequent association of H. heilmannii infection and gastric MALT lymphoma is coincidental, and whether H. heilmannii gastritis is more commonly associated with MALT lymphoma than is H. pylori gastritis must be investigated in further studies.