Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behavior
Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behavior
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DOI：
10.1016/j.bbr.2004.02.003
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发表时间：
2004-09-23
影响因子：
2.7
通讯作者：
Caulder, T
中科院分区：
文献类型：
--
作者：
Janak, PH;Chen, MT;Caulder, T
奖赏寻求行为的神经相关性在丘脑核（NAC）中观察到。这些相关的奖励的存在下的依赖性进行了研究，通过比较的行为相关性时观察到的奖励的存在被操纵在一个单一的行为会话。对大鼠进行良好的连续强化工具任务训练，通过0.1 ml滴加5%蔗糖进行强化。细胞外单单位神经活动记录从电极阵列植入NAC时，仪器的行为，然后没有加强与蔗糖（会话内灭绝）。仪器响应和蔗糖递送之间的可变延迟允许分离与这些任务事件相关的神经活动。在仪器响应时间周围的尖峰活动增加是最常见的行为相关性，而蔗糖递送后尖峰活动减少是第二常见的行为相关性。在去除抑制剂后，受试者继续进行仪器反应，允许在消退条件下检查反应相关的尖峰活动，其中反应不再被蔗糖加强。当蔗糖不再可用时，大多数与反应相关的神经活动模式丢失。在此期间还检测到新的神经反应。对于某些受试者，在同一次会议期间再次提供强化剂。在此期间的恢复性反应器的主要行为事件的编码是相似的，但不完全相同，在第一个时期的强化反应。这些研究结果表明，工具任务相关的尖峰活动内的NAC是部分依赖于存在的编码器，整个人口是不同的加强和灭绝条件下。(C)2004 Elsevier B.V.保留所有权利。
Neural correlates of reward-seeking behavior are observed in the nucleus accumbens (NAC). The dependence of these correlates upon the presence of a reward was studied by comparing the behavioral correlates observed when the presence of the reward was manipulated within a single behavioral session. Rats were well-trained on a continuous reinforcement instrumental task reinforced by 0.1 ml drops of 5% sucrose. Extracellular single-unit neural activity was recorded from electrode arrays implanted into the NAC when instrumental behavior was and then was not reinforced with sucrose (within-session extinction). A variable delay between the instrumental response and the sucrose delivery allowed for separation of neural activity related to these task events. A spike activity increase around the time of the instrumental response was the most common behavioral correlate, while a decrease in spike activity upon sucrose delivery was the second most common behavioral correlate. Following removal of the reinforcer, subjects continued to perform the instrumental response, allowing for the examination of response-related spike activity under extinction conditions in which the response was no longer reinforced by sucrose. A majority of the response-related neural activity patterns were lost when sucrose was no longer available. New neural responses also were detected during this period. For some subjects, the reinforcer was again made available during the same session. Encoding of the primary behavioral events during this period of reinstated reinforcer was similar, but not identical, to that observed during the first period of reinforced responding. These findings reveal that instrumental task-associated spike activity within the NAC is partially dependent upon the presence of the reinforcer, and that encoding across the population is distinct under reinforced and extinction conditions. (C) 2004 Elsevier B.V. All rights reserved.