Tyrosine kinase activation by PAF leads to downstream gene expression.
Tyrosine kinase activation by PAF leads to downstream gene expression.
复制标题
PAF 激活酪氨酸激酶导致下游基因表达。
DOI：
10.1007/978-1-4899-0179-8_25
复制
发表时间：
1996
影响因子：
--
通讯作者：
Shukla,SD
中科院分区：
文献类型：
--
作者：
Shukla,SD
过去十年的发展突显了由PAF受体(PAF-R)激活的信号转导通路的复杂性(Shukla，1992；Shimizuet al.，1992)。这些信号步骤中涉及的单个成分的分子细节和身份还有待解决。从更广泛的角度来看，PAF受体激活两条主要途径：(A)通过(C、D和A2型)磷脂酶介导的；(B)蛋白激酶(即PKC、酪氨酸激酶、MAP激酶)。此外，钙离子动员(细胞内释放、内流)也发挥着重要作用(James-Krackeet al.，1994)。这多条途径是如何导致PAF诱导的基因表达的，这是本文的主题。
Developments in the past decade have highlighted the complexity of signal transduction pathways activated by PAF receptor (PAF-R) (Shukla, 1992; Shimizuet al.,1992). Molecular details and identities of individual components involved in these signalling steps have yet to be resolved. In a broader perspective, PAF receptor activates two major pathways (a) mediated via phospholipases (of types C, D, and A2) and (b) protein kinases (i.e., PKC, tyrosine kinase, MAP kinase). Further, Ca2+mobilization (intracellular release, influx) also play important roles (James-Krackeet al.,1994). How these multiple pathways lead to expression of genes induced by PAF is the topic of this article.