Modulation of Fibroblasts in Conjunctival Wound Healing
Modulation of Fibroblasts in Conjunctival Wound Healing
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DOI：
10.1016/j.ophtha.2017.08.028
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发表时间：
2018-02-01
期刊：
影响因子：
13.7
通讯作者：
White, Andrew
中科院分区：
文献类型：
--
作者：
Zada, Mark;Pattamatta, Ushasree;White, Andrew
调节结膜伤口愈合有可能改善青光眼滤过手术后和几种眼部疾病（包括眼瘢痕性类天疱疮、春季角结膜炎和翼状胬肉）的结局。虽然抗炎药和抗代谢药已被成功使用，但这些非特异性药物并非没有并发症。寻找新的和更有针对性的手段来控制结膜纤维化，而没有这样的限制已经引起了人们对成纤维细胞增殖，分化，细胞外基质产生和细胞凋亡的调节的关注。这篇综述提供了一个更新，我们站在目前的抗纤维化药物，并概述了新的代理商使用的策略，因为他们从板凳上演变到床边。(C)2017年美国眼科学会
Modulating conjunctival wound healing has the potential to improve outcomes after glaucoma filtration surgery and for several ocular disorders, including ocular cicatrial pemphigoid, vernal keratoconjunctivitis, and pterygium. Although anti-inflammatories and antimetabolites have been used with success, these nonspecific agents are not without their complications. The search for novel and more targeted means to control conjunctival fibrosis without such limitations has brought much attention to the regulation of fibroblast proliferation, differentiation, extracellular matrix production, and apoptosis. This review provides an update on where we stand with current antifibrotic agents and outlines the strategies that novel agents use, as they evolve from the bench to the bedside. (C) 2017 by the American Academy of Ophthalmology