MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice
MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice
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DOI：
10.1055/s-0037-1604404
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发表时间：
2018-02-01
期刊：
影响因子：
1.4
通讯作者：
Rostasy, Kevin
中科院分区：
文献类型：
--
作者：
Hennes, Eva-Maria;Baumann, Matthias;Rostasy, Kevin
在所有患有急性脱髓鞘综合征(ADS)的儿童中，三分之一存在髓鞘少突胶质细胞糖蛋白(MOG)抗体(Abs)。MOG-Abs可见于急性播散性脑脊髓炎(ADEM)、横断性脊髓炎、孤立性视神经炎(ON)或复发性脱髓鞘疾病，如无水通道蛋白-4(AQP4)abs的多相神经脊髓炎视神经谱系疾病(NMOSD)或多相ADEM(MDEM)，但很少见于随后发展为多发性硬化(MS)的儿童。MOG-abs的存在与年龄有关，在幼儿和ADEM发作中发现的血清阳性率最高，而患有MOG-abs的较大儿童出现ON、脊髓炎或脑干症状。最初被认为与良性疾病病程有关的mog-abs，在相当大比例的复发发作的儿童中发现，与高且持续的mog-ab滴度有关。这篇综述特别描述了与MOG-abs相关的越来越多的表型谱，重点介绍了临床特征、放射学特征和治疗方面。
Myelin oligodendrocyte glycoprotein (MOG) antibodies (abs) are present in one third of all children with an acute demyelinating syndrome (ADS). MOG-abs can be found in acute disseminated encephalomyelitis (ADEM), transverse myelitis, isolated optic neuritis (ON), or recurrent demyelinating diseases, such as multiphasic neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 (AQP4) abs or multiphasic ADEM (MDEM), but rarely in children who subsequently develop multiple sclerosis (MS). The presence of MOG-abs is age dependent with the highest seropositivity rates found in young children and an episode of ADEM, whereas older children with MOG-abs present with ON, myelitis, or brainstem symptoms. MOG-abs, initially thought to be associated with a benign disease course, are found in a substantial proportion of children with relapsing episodes associated with high and persisting MOG-ab titers. This review describes, in particular, the increasing spectrum of phenotypes associated with MOG-abs with a focus on clinical characteristics, radiological features, and therapeutic aspects.