Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma.
Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma.
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DOI：
10.1097/md.0000000000026597
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发表时间：
2021-07-16
期刊：
影响因子：
1.6
通讯作者：
Pu H
中科院分区：
文献类型：
--
作者：
Liu L;Lu Z;Hu X;Su T;Su L;Pu H
食管癌是世界上第八常见和第六致命的癌症。本研究旨在探讨食管鳞状细胞癌（ESCC）患者外周血中YES相关蛋白1（YAP 1）和转录辅激活因子（TAZ）表达的临床特征及其与预后的关系。2008年1月至2018年12月期间，共收集了306例ESCC病理标本和邻近组织（作为对照;来自肿瘤边缘>5 cm的食管粘膜组织）。采用免疫组织化学方法检测YAP 1和TAZ蛋白在食管鳞癌及癌旁组织中的表达，并应用SPSS 21.0软件分析其与临床病理参数的关系。YAP 1和TAZ蛋白在食管鳞癌中高表达，其表达与TNM分期和淋巴结转移密切相关。YAP 1的表达与肿瘤大小（P = 0.029）、分化程度（P = 0.000）、浸润深度（P = 0.001）和TNM分期（P = 0.000）相关。 TAZ的表达与肿瘤大小（P = 0.034）、分化程度（P = 0.000）、浸润深度（P = 0.029）、淋巴结转移（P = 0.006）和种族（P <0.001）相关。 YAP 1蛋白表达与TAZ蛋白表达呈正相关（r = 0.257，P <0.05）。 YAP 1和TAZ表达（分别为P = 0.039和0.000）、肿瘤大小（P = 0.041）和淋巴结转移（P = 0.001）显著影响ESCC患者的总生存率，并代表总生存率的独立因素。 YAP 1和TAZ蛋白在食管鳞癌中高表达，且与肿瘤直径、分化程度、浸润深度等临床病理参数密切相关，提示YAP 1和TAZ可能参与食管鳞癌的发生发展。YAP 1和TAZ可作为食管鳞癌的预后指标。
Esophageal cancer is the eighth most frequent and sixth most fatal cancer worldwide. This study aimed to investigate the clinical characteristics and prognostic significance of yes related protein 1 (YAP1) and transcriptional co-activator with PDZ binding motif (TAZ) in patients with esophageal squamous cell carcinoma (ESCC). A total of 306 ESCC pathological specimens and adjacent tissues (as control; tissues from the esophageal mucosa >5 cm from the edge of the tumor) were collected between January, 2008 and December, 2018. Immunohistochemical staining was used to assess the expression of YAP1 and TAZ proteins in the ESCC and adjacent tissues, and their relationship with clinicopathological parameters was evaluated using SPSS 21.0 software. YAP1 and TAZ proteins were highly expressed in ESCC, and their expression was closely related to TNM stage and lymph node metastasis. Expression of YAP1 was associated with tumor size (P = .029), differentiation (P = .000), depth of invasion (P = .001), and TNM stage (P = .000). Expression of TAZ was associated with tumor size (P = .034), differentiation (P = .000), depth of invasion (P = .029), lymph node metastasis (P = .006), and ethnicity (P < .001). The expression of YAP1 protein was positively correlated with the expression of TAZ protein (r = 0.257, P < .05). YAP1 and TAZ expression (P = .039 and .000, respectively), tumor size (P = .041), and lymph node metastasis (P = .001) significantly affected the overall survival of patients with ESCC, and represent independent factors for overall survival. YAP1 and TAZ proteins are highly expressed in ESCC, and closely related to the clinical and pathological parameters such as the diameter of the tumor, degree of differentiation, and depth of invasion, indicating that YAP1 and TAZ may be involved in the development of ESCC. YAP1 and TAZ may be used as prognostic markers in ESCC.