Leptin disinhibits nonshivering thermogenesis in infants after maternal separation
Leptin disinhibits nonshivering thermogenesis in infants after maternal separation
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DOI：
10.1152/ajpregu.1999.276.2.r606
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发表时间：
1999-02-01
影响因子：
2.8
通讯作者：
Kirby, RF
中科院分区：
文献类型：
--
作者：
Blumberg, MS;Deaver, K;Kirby, RF
长时间的母婴分离会抑制暴露在寒冷中的哺乳动物幼崽的内源性产热。这种生热抑制发生在能量储存完全耗尽之前的许多小时。在分离诱导的饥饿过程中，保护能量来源的需要可能通过瘦素水平的下降来发出信号，瘦素是一种充当“脂肪信号”和能量利用调节器的激素;事实上，饥饿会降低成年小鼠和幼年大鼠的瘦素水平。然而，瘦素在婴儿饥饿期间是否具有功能性作用尚不清楚。这种作用可以在棕色脂肪组织（BAT）的非颤抖性产热调节中发现，棕色脂肪组织是一种专门的器官，在寒冷暴露期间为婴儿哺乳动物（包括人类）提供热量。BAT产生的热量使暴露在寒冷中的婴儿能够防止体温过低对生理和行为以及最终对生长的不利影响。在这里，我们表明，瘦素disinhibit BAT产热过程中冷暴露在婴儿大鼠后18小时的母亲分离。这一发现表明，瘦素不仅仅是一种调节体重的脂肪，具体地说，瘦素在出生后早期调节产热和能量利用。
Prolonged maternal separation inhibits endogenous heat production in infant mammals exposed to cold. This inhibition of thermogenesis occurs many hours before energy stores have been fully depleted. The need to protect energy re; sources during separation-induced starvation may be signaled by declining levels of leptin, a hormone that acts as a "fat signal" and a regulator of energy utilization; in fact, starvation reduces leptin levels in adult mice and infant rats. It is not known, however, whether leptin has a functional role during starvation in infants. Such a role may be found in the regulation of nonshivering thermogenesis by brown adipose tissue (BAT), a specialized organ that provides heat to infant mammals, including humans, during cold exposure. Heat produced by BAT allows the cold-exposed infant to prevent the detrimental effects of hypothermia on physiology and behavior and, ultimately, growth. Here we show that leptin disinhibits BAT thermogenesis during cold exposure in infant rats after 18 h of maternal separation. This finding demonstrates that; leptin is more than simply an adipostat for the regulation of body weight; specifically, leptin modulates thermogenesis and energy utilization in the early postnatal period.