Correlation Between NT-Pro BNP Levels and Left Ventricular Wall Stress, Sphericity Index and Extent of Myocardial Damage: A Magnetic Resonance Imaging Study
Correlation Between NT-Pro BNP Levels and Left Ventricular Wall Stress, Sphericity Index and Extent of Myocardial Damage: A Magnetic Resonance Imaging Study
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DOI：
10.1016/j.cardfail.2008.05.002
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发表时间：
2008-10-01
影响因子：
6
通讯作者：
Udompunturak, Suthipol
中科院分区：
文献类型：
--
作者：
Krittayaphong, Rungroj;Boonyasirinant, Thananya;Udompunturak, Suthipol
背景：探讨冠状动脉疾病患者左室壁运动异常与左室壁应力、球形指数、功能及心肌损害程度的关系。方法与结果：所有患者均行心脏磁共振成像（CMR）检查。测量了球度指数和壁应力。从延迟增强图像中计算心肌瘢痕的百分比。评价log NT-pro BNP水平与各参数的相关性。125例患者，平均年龄62.6±9.6岁。NT-proBNP的中位水平为1012 pg/mL。平均左室射血分数（LVEF）为37±14.4%。Log NT-proBNP水平与壁应力、球度指数、左心室呈正相关。尺寸、体积、质量、壁运动评分、心肌瘢痕程度和年龄，并与肌酐清除率、LVEF、卒中容积和体型呈负相关。多元线性回归分析显示，舒张和收缩壁应力和收缩球度指数是log NT-proBNP水平的独立预测因子。结论：NT-proBNP水平与左室壁应力密切相关，与球度指数中度相关。[J]; journal of chengdu electro - chengdu electro - chengdu electro - chengdu electro - chengdu。
Background: To determine the relationship between N-terminal pro-brain natriuretic peptide (NT-pro BNP) levels and left ventricular wall stress, sphericity index, function, and extent of myocardial damage in patients with coronary artery disease and abnormal left ventricular wall motion.Methods and Results: All patients underwent cardiac magnetic resonance imaging (CMR). Measurements of sphericity index and wall stress were performed. Percentages of myocardial scarring were calculated from delayed-enhancement images. Correlations between log NT-pro BNP levels and various parameters were evaluated. There were 125 patients with an average age of 62.6 +/- 9.6 years. Median levels of NT-proBNP were 1012 pg/mL. Average left ventricular ejection fraction (LVEF) was 37 +/- 14.4%. Log NT-proBNP levels had positive correlations with wall stress, sphericity index, left ventricular. dimension, volume, mass, wall motion score, extent of myocardial scarring, and age, and had negative correlations with creatinine clearance, LVEF, stroke volume, and body size. Multiple linear regression analysis showed that diastolic and systolic wall stress and systolic sphericity index were independent predictors for log NT-proBNP levels.Conclusions: NT-proBNP levels strongly correlated with left ventricular wall stress and moderately correlated with sphericity index. (J Cardiac Fail 2008;14:687-694)