Systemic F2-Isoprostane Levels in Predisposition to Obesity and Type 2 Diabetes: Emphasis on Racial Differences.
Systemic F2-Isoprostane Levels in Predisposition to Obesity and Type 2 Diabetes: Emphasis on Racial Differences.
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DOI：
10.21767/2049-5471.100098
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Okosun, Ike S
中科院分区：
文献类型：
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作者：
Il'yasova, Dora;Wong, Brett J;Okosun, Ike S
本文综述了脂质过氧化标记物F2-异前列腺素作为肥胖和2型糖尿病易感代谢特征的全身水平的种族差异。在肥胖、2型糖尿病及其合并症中发现F2-异前列腺素水平升高。据推测，增加的F2-异前列烷水平反映了肥胖诱导的氧化应激，促进2型糖尿病的发展。然而，非裔美国人尽管有肥胖和2型糖尿病的易感性，但全身F2-异前列烷水平较低。综述总结了流行病学研究的新发现和一种新的解释全身F2-异前列烷水平的代谢决定因素作为一个有利的表型。多项观察结果表明，全身F2-异前列烷水平反映了氧化代谢的强度，这是活性氧的主要内源性来源，特别是脂肪利用的强度。来自多项人类研究的证据表明，针对脂肪代谢可能是解决现有种族健康差异的有效种族特异性策略。尿F2-异前列腺素可能为预防非洲裔人群肥胖和2型糖尿病的有针对性的干预措施提供基础。
This review focuses on racial differences in systemic levels of lipid peroxidation markers F2-isoprostanes as metabolic characteristics predisposing to obesity and type 2 diabetes. Elevated levels F2-isoprostanes were found in obesity, type 2 diabetes and their comorbidities. It was hypothesized that increased F2-isoprostane levels reflect the obesity-induced oxidative stress that promotes the development of type 2 diabetes. However, African Americans have lower levels of systemic F2-isoprostane levels despite their predisposition to obesity and type 2 diabetes. The review summarizes new findings from epidemiological studies and a novel interpretation of metabolic determinants of systemic F2-isoprostane levels as a favorable phenotype. Multiple observations indicate that systemic F2-isoprostane levels reflect intensity of oxidative metabolism, a major endogenous source of reactive oxygen species, and specifically, the intensity of fat utilization. Evidence from multiple human studies proposes that targeting fat metabolism can be a productive race-specific strategy to address the existing racial health disparities. Urinary F2-isoprostanes may provide the basis for targeted interventions to prevent obesity and type 2 diabetes among populations of African descent.