YAP suppresses human T-cell leukemia virus type 1 transcription
YAP suppresses human T-cell leukemia virus type 1 transcription
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DOI：
10.1002/jmv.29065
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发表时间：
2023-09-01
影响因子：
12.7
通讯作者：
Zhao，Tiejun
中科院分区：
文献类型：
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作者：
Li，Hengbo;Zou，Feng;Zhao，Tiejun
人类T细胞白血病病毒1型（HTLV-1）是第一种被鉴定为人类疾病病原体的人类逆转录病毒，包括成人T细胞白血病/淋巴瘤（ATL）和HTLV-1相关脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）。1，2经过几十年的长期潜伏期后，大约3%-5%的HTLV-1感染者会发展为ATL。1细胞中的高HTLV-1前病毒负荷似乎是ATL发展的主要风险。了解HTLV-1调节病毒转录的机制可能为预防HTLV-1相关疾病的策略提供有价值的见解。HTLV-1前病毒基因组长约9000 bp，两端均为长末端重复序列（LTR）。4除了必需的逆转录病毒结构蛋白，如gag，pol和env，HTLV-1前病毒基因组的特征是在env和3 'LTR之间存在独特的pX区域。pX区编码几种病毒调节蛋白，包括Tax、雷克斯、p12、p13、p30和HTLV-1 bZIP因子（HBZ）。1，5其中，税收和HBZ通过调节，对ATL的发展起着关键作用。
Human T‐cell leukemia virus type 1 (HTLV‐1) is the first human retrovirus to be identified as the causative agent of human diseases including adult T‐cell leukemia/lymphoma (ATL) and HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). 1, 2 After a long latent period of several decades, approximately 3%–5% of HTLV‐1‐infected individuals develop ATL. 1 High HTLV‐1 proviral load in cells seems to be the major risk for the development of ATL. 3 Understanding the mechanism by which HTLV‐1 regulates viral transcription might provide valuable insight into the strategies for prevention of HTLV‐1 associated diseases. The HTLV‐1 proviral genome is approximately 9000 bp long and flanked by long terminal repeat (LTR) sequences at both ends. 4 In addition to essential retroviral structural proteins, such as gag, pol, and env, the characteristic of HTLV‐1 proviral genome is the presence of a unique pX region between env and the 3'LTR. 4 The pX region encodes several viral regulatory proteins including Tax, Rex, p12, p13, p30, and HTLV‐1 bZIP factor (HBZ). 1, 5 Among them, Tax and HBZ play critical roles in the development of ATL by regulating