Ultrasound-induced encapsulated microbubble phenomena
Ultrasound-induced encapsulated microbubble phenomena
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DOI：
10.1016/j.ultrasmedbio.2004.02.010
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发表时间：
2004-06-01
影响因子：
2.9
通讯作者：
De Jong, N
中科院分区：
文献类型：
--
作者：
Postema, M;Van Wamel, A;De Jong, N
当封装的微泡受到高振幅的超声，以下现象已被报道：振荡，平移，聚结，破碎，声破裂和喷射。在本文中，我们解释了这些现象，根据理论，验证了相对较大的，自由（未封装）的气泡。这些理论进行了比较与高速光学观察声造影剂微泡。此外，气泡-超声相互作用的潜在临床应用进行了探讨。我们的结论是，所获得的结果与自由气泡理论是一致的。与空化理论相似，气泡分裂后的碎片数与占主导地位的球谐振荡模式一致。值得注意的是，我们的观察喷射通过造影剂微泡。射流尖端的压力足以穿透任何人体细胞。因此，液体射流可以充当远程控制的微量注射器，将药物递送到感兴趣的区域。包封的微泡在诊断学和治疗学中具有（潜在的）临床应用。（电子邮件：m. erasmusmc.nl）（C）2004年世界医学超声生物学联合会。
When encapsulated microbubbles are subjected to high-amplitude ultrasound, the following phenomena have been reported: oscillation, translation, coalescence, fragmentation, sonic cracking and jetting. In this paper, we explain these phenomena, based on theories that were validated for relatively big, free (not encapsulated) gas bubbles. These theories are compared with high-speed optical observations of insonified contrast agent microbubbles. Furthermore, the potential clinical applications of the bubble-ultrasound interaction are explored. We conclude that most of the results obtained are consistent with free gas bubble theory. Similar to cavitation theory, the number of fragments after bubble fission is in agreement with the dominant spherical harmonic oscillation mode. Remarkable are our observations of jetting through contrast agent microbubbles. The pressure at the tip of a jet is high enough to penetrate any human cell. Hence, liquid jets may act as remote-controlled microsyringes, delivering a drug to a region-of-interest. Encapsulated microbubbles have (potential) clinical applications in both diagnostics and therapeutics. (E-mail: m.postema@erasmusmc.nl) (C) 2004 World Federation for Ultrasound in Medicine Biology.