Early decrease in blood lymphocyte count is associated with poor prognosis in COVID-19 patients: a retrospective cohort study.
Early decrease in blood lymphocyte count is associated with poor prognosis in COVID-19 patients: a retrospective cohort study.
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血液淋巴细胞计数早期下降与COVID-19患者预后不良相关：一项回顾性队列研究
DOI：
10.1186/s12890-023-02767-z
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发表时间：
2023-11-20
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
此前的研究已经宣布，基线淋巴细胞计数与COVID-19相关死亡相关。然而，淋巴细胞随时间的动态变化是否会影响COVID-19患者的预后尚不清楚。本研究旨在探讨淋巴细胞计数在COVID-19患者疾病进展过程中的意义。回顾性队列研究招募了2020年1月7日至2020年2月28日在武汉市江夏区第一人民医院接受治疗的COVID-19患者。收集人口统计学资料、病史、血常规检查结果和患者结局。我们利用广义相加混合模型比较了存活者和非存活者淋巴细胞计数随时间的变化趋势，并对潜在混杂因素进行了调整。统计分析采用R软件和EmpowerStats。在P值小于0.05（双侧）时确定显著性。共有532名患者被纳入研究。总的来说，有29/532例住院死亡（5.45%）。在住院的前10天，非幸存者组的淋巴细胞随着时间的推移而下降，而幸存者组的淋巴细胞随着时间的推移而增加。入院后10天内，存活组淋巴细胞计数升高，死亡组淋巴细胞计数降低。存活者与死亡者淋巴细胞计数之差平均每天增加0.0732 × 109/L。在调整多个协变量后，增加值仍为0.0731 × 109/L/d。在早期阶段，淋巴细胞计数可以动态反映COVID-19患者的病理生理变化。淋巴细胞计数的早期减少与COVID-19患者的死亡率相关。
Previous studies have declared that baseline lymphocyte count is associated with COVID-19-related death. However, whether dynamic lymphocyte change over time affects prognosis in COVID-19 patients is unknown. This study aims to investigate the significance of lymphocyte count during the progression of the disease in COVID-19 patients. The retrospective cohort study recruited COVID-19 patients at the First People’s Hospital of Jiangxia District in Wuhan from January 7, 2020, to February 28, 2020. The demographics, medical histories, results of the blood routine test, and patients’ outcomes were collected. We utilized a generalized additive mixed model to compare trends in lymphocyte count over time among survivors and non-survivors, with an adjustment for potential confounders. The statistical analysis used R software and EmpowerStats. Significance was determined at a P-value of less than 0.05 (two-sided). A total of 532 patients were included in the study. Overall, there were 29/532 in-hospital deaths (5.45%). Lymphocytes declined over time in the non-survivor group and increased in the survivor group in the first 10 days of hospitalization. Within 10 days after admission, lymphocyte count increased in the survivor group and decreased in the non-survivor group. The difference in lymphocyte counts between survivors and non-survivors increased by an average of 0.0732 × 109/L daily. After adjusting for several covariables, the increasing value remained at 0.0731 × 109/L per day. In the early stage, lymphocyte count can dynamically reflect the pathophysiological changes in COVID-19 patients. An early decrease in lymphocyte count is associated with mortality in COVID-19 patients.
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影响因子：
2.3
作者：
Yildiz H;Castanares-Zapatero D;Pierman G;Pothen L;De Greef J;Aboubakar Nana F;Rodriguez-Villalobos H;Belkhir L;Yombi JC
通讯作者：
Yombi JC
影响因子：
3.7
作者：
Xiong S;Liu L;Lin F;Shi J;Han L;Liu H;He L;Jiang Q;Wang Z;Fu W;Li Z;Lu Q;Chen Z;Ding S
通讯作者：
Ding S
影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
24
作者：
Najjar, Samer S.;Scuteri, Angelo;Lakatta, Edward G.
通讯作者：
Lakatta, Edward G.
影响因子：
28.2
作者：
Liu, Yuwei;Du, Xuebei;Zhao, Yan
通讯作者：
Zhao, Yan